Low-molecular-weight adiponectin is more closely associated with disease activity of rheumatoid arthritis than other adiponectin multimeric forms

Clinical Rheumatology
Ping LiLi-qi Bi

Abstract

Adiponectin is divided into high-molecular-weight (HMW), medium-molecular-weight (MMW), and low-molecular-weight (LMW) forms. These forms differ not only in the number of adiponectin molecules but also in their biological activity. There are conflicting findings regarding the role of adiponectin in rheumatoid arthritis (RA). Moreover, few reports have described the relationships between serum adiponectin multimers levels and RA. Therefore, we examined the association of total adiponectin and its multimers with RA. Two study groups were examined: 180 recently diagnosed untreated RA patients with disease duration less than 1 year (RA group) and 160 age- and sex-matched control subjects (control group). RA-related factors, blood pressure, body mass index, glucose, complete lipid profile, and adiponectin multimers were measured. The levels of total adiponectin and each multimer of adiponectin were significantly lower in the RA than in the control (P < 0.01). Serum levels of total, HMW, MMW, and LMW were positively correlated with triglycerides levels and negatively correlated with the Disease Activity Score for 28 joints (DAS28). Multivariate regression analysis showed that total, HMW, and MMW adiponectin were independently associa...Continue Reading

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Citations

Aug 27, 2015·International Immunopharmacology·Ding LiuZhihong Li
Jul 5, 2016·Pharmacology & Therapeutics·Linda SwedinMatthew C Catley
Aug 20, 2016·International Journal of Rheumatic Diseases·Vishad Viswanath, Debashish Danda
Feb 17, 2017·International Journal of Rheumatic Diseases·Young Ho Lee, Sang-Cheol Bae
Feb 27, 2019·Archives of Dermatological Research·Jakub ŻółkiewiczLidia Rudnicka
Dec 28, 2019·Journal of Clinical Laboratory Analysis·Kun LianQin Wang
Nov 16, 2017·Clinical Chemistry·Krasimira AleksandrovaTobias Pischon
Oct 3, 2018·Aging and Disease·Stefano RizzaMassimo Federici
Jun 20, 2019·Rheumatology International·Mirjana B BećarevićSvetlana D Ignjatović
Feb 2, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Mukanthu H NyirendaAmit Bar-Or
Nov 8, 2020·International Journal of Molecular Sciences·Kamila SzumilasAndrzej Pawlik

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