Low-Molecular-Weight Compound GSB-106 Mimics the Cellular Effects of BDNF after Serum Deprivation

Doklady. Biochemistry and Biophysics
L F ZainullinaS B Seredenin

Abstract

The in vitro model of serum deprivation shows that the survival of SH-SY5Y neuronal cells is ensured by the intrinsic trophic activity of BDNF loop 4 mimetic GSB-106 (10-7 М), which is comparable to that of endogenous neurotrophin (10-9 М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G1 phase, diminishes the number of cells in the S-phase, reduces the number of apoptotic cells, and does not stimulate proliferation.

References

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Mar 2, 2011·Nature Reviews. Drug Discovery·Alan H Nagahara, Mark H Tuszynski
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Mar 1, 2017·Bulletin of Experimental Biology and Medicine·T A GudashevaS B Seredenin

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Methods Mentioned

BETA
pharmacotherapy
Flow
Assay
flow cytometry

Software Mentioned

NovoExpress

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