Low-molecular-weight compounds with anticoagulant activity from the scorpion Heterometrus laoticus venom

Doklady. Biochemistry and Biophysics
Tran Vu ThienYu N Utkin

Abstract

Low-molecular-weight compounds with anticoagulant activity were isolated from the scorpion Heterometrus laoticus venom. The determination of the structure of the isolated compounds by nuclear magnetic resonance and mass spectrometry showed that one of the isolated compounds is adenosine, and the other two are dipeptides leucyl-tryptophan and isoleucyl-tryptophan. The anticoagulant properties of adenosine, which is an inhibitor of platelet aggregation, is well known, but its presence in scorpion venom is shown for the first time. The ability of leucyl-tryptophan and isoleucyl-tryptophan to slow down blood clotting and their presence in scorpion venom are also established for the first time.

References

Oct 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·N H Tan, G Ponnudurai
Sep 16, 1983·European Journal of Pharmacology·R E Klabunde
Jun 25, 2005·Toxicon : Official Journal of the International Society on Toxinology·Yi-Min SongXin-Ran Lv
Nov 19, 2008·Archives of Toxicology·Josmary BrazónBelsy Guerrero
Nov 6, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Angelika SchedelPeter Bugert
Jun 28, 2011·Biochemical and Biophysical Research Communications·Peter V DubovskiiAlexander S Arseniev
Apr 20, 2012·World Journal of Experimental Medicine·Yang LiuXiao-Jun Du

❮ Previous
Next ❯

Citations

May 16, 2020·Biomedicines·Shirin AhmadiAndreas H Laustsen
Aug 6, 2020·Biomedicines·Edward R J EvansDavid T Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.