Low Molecular Weight Heparin-Coated and Dendrimer-Based Core-Shell Nanoplatform with Enhanced Immune Activation and Multiple Anti-Metastatic Effects for Melanoma Treatment

Theranostics
Chunyu XiaQin He

Abstract

High-efficiency treatment for tumor is not easy to achieve owing to the existence of metastasis, which remains the arch-criminal of most tumor deaths. Conventional chemotherapy exhibits insufficient inhibitory efficiency on tumor metastasis and more powerful strategies to conquer metastatic tumors are urgently needed. In this study, a rational chemoimmunotherapy strategy was adopted to treat highly aggressive melanoma based on a newly developed multifunctional nanoplatform. Firstly, immunoadjuvant cytosine-phosphate-guanine oligonucleotides (CpG ODNs) were used to boost the doxorubicin (DOX)-elicited immune responses, which synergistically suppressed tumor growth and metastasis. And the anti-metastatic low molecular weight heparin (LMWH) was also integrated, thus multiple anti-metastatic effects to against tumor metastasis were achieved. Methods: G4 PAMAM was serving as the main support to conjugate DOX by pH-sensitive hydrazone bond (PPD) and the synthesized conjugates were confirmed by 1H-NMR spectra, IR spectra and HRMS. Immunoadjuvant CpG ODNs were loaded by electrostatic adsorption to formulate PPD/CpG. After the coating of anti-metastatic LMWH, the designed LMWH/PPD/CpG was fabricated and characterized. The platelets-rela...Continue Reading

Citations

Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberta CassanoSonia Trombino
Apr 6, 2021·Bioactive Materials·Yujun ZengKui Luo
Jun 18, 2021·Nano-micro Letters·Weiwei MuNa Zhang
Jul 28, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Asmita BanstolaSimmyung Yook
Aug 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Harsimran Kaur, Prashant Kesharwani
Mar 3, 2020·Advanced Drug Delivery Reviews·Livia Neves Borgheti-CardosoMaria Vitória Lopes Badra Bentley
Nov 2, 2020·European Journal of Pharmacology·Arya Kadukkattil RamanunnyNarendra Kumar Pandey

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Methods Mentioned

BETA
electrophoresis
FRET
amidation
dynamic light scattering
fluorescence imaging
flow cytometry
ELISA
flow
confocal microscopy

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