Low-molecular-weight heparins and angiogenesis

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
K Norrby

Abstract

The involvement of the vascular system in malignancy encompasses not only angiogenesis, but also systemic hypercoagulability and a pro-thrombotic state, and there is increasing evidence that pathways of blood coagulation and angiogenesis are reciprocally linked. In fact, cancer atients often display hypercoagulability resulting in markedly increased thromboembolism, which requires anti-coagulant treatment using heparins, for example. Clinical trials reveal that treatment with various low-molecular-weight heparins (LMWHs) improves the survival time in cancer patients receiving chemotherapy compared with those receiving unfractionated standard heparin (UFH) or no heparin treatment, as well as in cancer patients receiving LMWH as thrombosis prophylaxis during primary surgery. This anti-tumor effect of the heparins appears to be unrelated to their anti-coagulant activity, but the mechanisms involved are not fully understood. Tumor growth and spread are dependent on angiogenesis and it is noteworthy that the most potent endogenous pro- and anti-angiogenic factors are heparin-binding proteins that may be affected by systemic treatment with heparins. Heparin and other glycosaminoglycans play a role in vascular endothelial cell functio...Continue Reading

References

Jan 1, 1992·Advances in Experimental Medicine and Biology·J Folkman, Y Shing
Jan 1, 1991·The Journal of Clinical Investigation·M L NierodzikS Karpatkin
Jan 1, 1990·Haemostasis·R AbbateG G Neri Serneri
Jan 1, 1990·Haemostasis·P A D'Amore
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K NorrbyJ Sörbo
Mar 17, 1989·Science·J FolkmanW R Ewing
Jan 15, 1970·International Journal of Cancer. Journal International Du Cancer·B Hagmar, K Norrby
Aug 12, 1971·The New England Journal of Medicine·J Folkman
Sep 1, 1994·The Journal of Clinical Investigation·Y ZhangP P Nawroth
Sep 15, 1994·Biochemical and Biophysical Research Communications·S SokerG Neufeld
Jul 1, 1994·Microvascular Research·K Norrby
Nov 27, 1995·International Journal of Cancer. Journal International Du Cancer·E J DerbyshireP E Thorpe
Jun 1, 1995·Trends in Pharmacological Sciences·D J TyrellC P Page
Sep 1, 1993·Journal of the American College of Cardiology·A A QuyyumiS E Epstein
Jan 1, 1996·International Journal of Microcirculation, Clinical and Experimental·K Norrby, P Ostergaard
Aug 23, 1996·Cancer Letters·R C MaiaV M Rumjanek
Jan 1, 1996·Intensive Care Medicine·J D Young, O J Dyar
Jan 1, 1997·British Journal of Cancer·G C Jayson, J T Gallagher
Jan 1, 1997·Seminars in Thrombosis and Hemostasis·W JeskeA Ahsan
Jun 1, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K Norrby
Sep 1, 1996·Current Opinion in Hematology·W Ruf, B M Mueller
Apr 4, 1998·International Journal of Microcirculation, Clinical and Experimental·K Norrby, P Ostergaard
Nov 5, 1999·Seminars in Thrombosis and Hemostasis·J FareedR L Bick
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 26, 2000·Carcinogenesis·R S Kerbel
May 10, 2000·Nature Medicine·I J Fidler, L M Ellis
Sep 6, 2000·British Journal of Clinical Pharmacology·P B SalbachI Walter-Sack
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Sep 30, 2000·Seminars in Thrombosis and Hemostasis·L R ZacharskiA C Mamourian
Jan 9, 2001·International Journal of Cancer. Journal International Du Cancer·K NorrbyS Tuneberg

❮ Previous
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Citations

Sep 17, 2009·Applied Microbiology and Biotechnology·Anaïs A E ChavarocheGerrit Eggink
Nov 1, 2011·International Orthopaedics·Kambiz SarahrudiSeyedhossein Aharinejad
Oct 13, 2007·Biomacromolecules·Hironobu TakahashiDavid W Grainger
Jul 3, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Inaam A Nakchbandi, J-Matthias Löhr
Apr 25, 2008·The Journal of Biological Chemistry·Edward N HarrisPaul H Weigel
Sep 10, 2013·Biochemistry. Biokhimii︠a︡·M A NugentJ L Spencer
Jan 30, 2009·Pathophysiology of Haemostasis and Thrombosis·Benito CasuRalph D Sanderson
Jun 30, 2011·Journal of Visualized Experiments : JoVE·Klas C Norrby
Aug 22, 2007·Mediators of Inflammation·Alexandros Basilios TsouprasConstantinos Alexandros Demopoulos
Feb 22, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Nurkay KatranciogluZubeyde Akin Polat
Jul 11, 2012·Oncogene·T KallunkiM Jäättelä
May 1, 2008·Expert Opinion on Drug Discovery·Klas Norrby
Apr 22, 2008·Expert Opinion on Pharmacotherapy·Tobias LindnerEleftherios Tsiridis
Mar 15, 2015·Annals of Medicine·Massimo Franchini, Pier Mannuccio Mannucci
Feb 13, 2008·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Nikunj S PatelDaniel Paris
Apr 17, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Rodrigo I BouçasHelena B Nader
Apr 14, 2012·Thrombosis Research·Eleonora Da PozzoRossella Di Stefano
Jun 12, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haining TanFengshan Wang
Mar 12, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lisa Barbera, Gillian Thomas
Jan 15, 2010·Journal of Pharmaceutical and Biomedical Analysis·Susanne LühnSusanne Alban
Mar 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuanke LiJing Yao
Jan 30, 2007·European Journal of Pharmacology·Jacek BorawskiMichal Mysliwiec
Sep 23, 2006·Journal of Cellular and Molecular Medicine·K Norrby
Jun 26, 2012·American Journal of Reproductive Immunology : AJRI·Celal Yavuz, Oğuz Karahan
Aug 21, 2013·Macromolecular Bioscience·Hazel PenicheJulio San Román
Aug 14, 2012·American Journal of Reproductive Immunology : AJRI·Celal Yavuz, Oğuz Karahan
Nov 26, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Klas Norrby, Arvid Nordenhem
Apr 7, 2016·Gene·İhsan AlurÇığır Biray Avcı
Apr 18, 2015·International Journal of Cell Biology·Madhu S PandeyPaul H Weigel
Jul 6, 2010·Biochemical and Biophysical Research Communications·Karthik Raman, Balagurunathan Kuberan
Oct 9, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seung Rim HwangYoungro Byun
Jan 22, 2013·Thrombosis Research·Ferhat SayMehmet Gönültaş
Jul 8, 2014·Cancer Treatment Reviews·Emilia MontagnaMarco Colleoni

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