PMID: 6972766Jun 1, 1981Paper

Low molecular weight IgM in rheumatoid arthritis and other rheumatic diseases

Arthritis and Rheumatism
P Roberts-ThomsonM Ziff

Abstract

Low molecular weight (LMW) IgM was measured in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and other rheumatic diseases. High levels were seen in RA, particularly in rheumatoid vasculitis and Felty's syndrome, and significant correlations occurred between LMW IgM and the rheumatoid factor (RF) level and other indices that reflected active or severe disease. LMW IgM-RF, measured by radioimmunoassay in those column fractions containing LMW IgM, correlated significantly with LMW IgM (P less than 0.005); preliminary experiments suggested that in some sera, a considerable proportion of the LMW IgM consisted of LMW IgM-RF. We conclude that LMW IgM and LMW IgM-RF may have important implications in the immunopathogenesis of RA and other rheumatic diseases.

References

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Citations

Jan 1, 1982·Rheumatology International·P J Roberts-ThomsonM Ziff
Dec 1, 1983·Clinical Rheumatology·D G Scott, P A Bacon
Apr 3, 1986·Journal of Immunological Methods·R HarriesP Roberts-Thomson
Aug 1, 1987·Journal of Reproductive Immunology·P J Roberts-ThomsonR H Harries
Nov 1, 1996·Human Immunology·H Xu, P J Roberts-Thomson
Dec 1, 1988·Archives of Disease in Childhood·P J Roberts-ThomsonJ Edmonds
Feb 1, 1988·Annals of the Rheumatic Diseases·P J Roberts-ThomsonL Y Koh
Jun 1, 1994·Annals of the Rheumatic Diseases·H XuP J Roberts-Thomson
Dec 2, 2004·Journal of Autoimmunity·Michele E YoudRonald B Corley
Nov 1, 1987·Clinical Immunology and Immunopathology·A C SundewallR Norberg
Apr 1, 1984·Australian and New Zealand Journal of Medicine·P J Roberts-ThomsonJ Bradley
Jan 1, 1982·Journal of Medical Virology·J NagingtonM P Cranage
Jan 1, 1985·Arthritis and Rheumatism·D N JonesP J Roberts-Thomson
Jan 1, 1990·Clinical and Laboratory Haematology·J P Ellis, R J Sokol
Mar 1, 1990·Clinical and Experimental Immunology·P J Roberts-Thomson, K Shepherd
Dec 1, 1982·Clinical Genetics·M KjellmanA G Sjöholm

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