Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum.

Malaria Journal
Olof HellgrenSergei V Drovetski

Abstract

Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14. The majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe. The results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep.

References

Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Mar 20, 2004·Nature Reviews. Microbiology·Andrés MoyaFernando González-Candelas
Sep 3, 2004·Evolution; International Journal of Organic Evolution·Staffan BenschOlof Hellgren
Sep 11, 2004·The Journal of Parasitology·Olof HellgrenStaffan Bensch
Feb 11, 2005·Molecular Biology and Evolution·A J DrummondO G Pybus
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jess A T MorganJohn W Taylor
Oct 25, 2008·BMC Evolutionary Biology·Joseph Heled, Alexei J Drummond
Oct 30, 2008·Nucleic Acids Research·Cristina AurrecoecheaHaiming Wang
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
May 11, 2010·International Journal for Parasitology·Madhusudan Kadekoppala, Anthony A Holder
Nov 22, 2011·Trends in Parasitology·Robin StephensTracey J Lamb
Aug 27, 2013·Bioinformatics·Fritz J SedlazeckArndt von Haeseler
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Dec 3, 2014·Experimental Parasitology·Dimitar DimitrovGediminas Valkiūnas
May 15, 2015·Parasitology·Luz Garcia-LongoriaAlfonso Marzal
Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Romain PigeaultAna Rivero
May 4, 2018·Malaria Journal·Gediminas ValkiūnasTatjana A Iezhova
Jun 26, 2018·Trends in Parasitology·Ana Rivero, Sylvain Gandon
Jan 16, 2019·Trends in Parasitology·Elin Videvall
May 30, 2020·The American Naturalist·Elin VidevallOlof Hellgren

❮ Previous
Next ❯

Software Mentioned

MarkDuplicates
Nextgenmap
Trimmomatic
Geneious Prime
PopArt
samtools
MrBayes
MUSCLE
Picard
PlasmoDB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.