Low multiple pregnancy rates and reduced frequency of cancellation after ovulation induction with gonadotropins, if eventual supernumerary follicles are aspirated to prevent polyovulation

Journal of Assisted Reproduction and Genetics
C De GeyterE Nieschlag

Abstract

Our purpose was to demonstrate the feasibility of the routine aspiration of supernumerary follicles in infertile patients with imminent polyovulation after ovulation induction with gonadotropins and to examine its effect on the frequency of cycle cancellation and on the (multiple) pregnancy rate. The data on 796 treatment cycles, performed between 1989 and 1996 on 410 infertile couples, were analyzed retrospectively. From October 1992, whenever necessary, supernumerary ovarian follicles were selectively aspirated transvaginally under ultrasound guidance to prevent the ovulation of more than three follicles. Thereafter, intrauterine insemination was performed. After the adoption of transvaginal ultrasound-guided aspiration of supernumerary follicles into the treatment protocol in October 1992, the number of canceled cycles (P < 0.0001) and the multiple pregnancy rate (P < 0.01) were significantly reduced compared to those previously. The overall pregnancy rate remained stable. No ovarian hyperstimulation syndrome requiring hospitalization was noted, and no complications resulting from the follicle aspiration were registered. Transvaginal ultrasound-guided aspiration of supernumerary ovarian follicles increases both the efficacy ...Continue Reading

Citations

Apr 9, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·O OlufowobiM Afnan
Aug 31, 2004·Gynecologic and Obstetric Investigation·B J Cohlen
Oct 31, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ramón AurellPedro N Barri
Jul 28, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Yiping ZhongXiaoting Shen
Dec 24, 2011·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine

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