Low nocturnal diastolic ocular perfusion pressure as a risk factor for NTG progression: a 5-year prospective study

Eye
Pushpa RamanNorlina Ramli

Abstract

To assess the relationship between baseline intraocular pressure (IOP), blood pressure (BP) and ocular perfusion pressure (OPP), and the 5-year visual field progression in normal-tension glaucoma (NTG) patients. Prospective, longitudinal study. Sixty-five NTG patients who were followed up for 5 years are included in this study. All the enrolled patients underwent baseline 24-h IOP and BP monitoring via 2-hourly measurements in their habitual position and were followed up for over 5 years with reliable VF tests. Modified Anderson criteria were used to assess VF progression. Univariable and multivariable analyses using Cox's proportional hazards model were used to identify the systemic and clinical risk factors that predict progression. Kaplan-Meier survival analyses were used to compare the time elapsed to confirmed VF progression in the presence or absence of each potential risk factor. At 5-year follow-up, 35.4% of the enrolled patients demonstrated visual field progression. There were statistically significant differences in the mean diastolic blood pressure (p < 0.05) and diastolic OPP (p < 0.05) between the progressing and the non-progressing group. There was no association between IOP parameters and NTG progression. Multiv...Continue Reading

References

Dec 26, 2001·Archives of Ophthalmology·H A QuigleyR Snyder
Aug 2, 2002·Progress in Retinal and Eye Research·Josef FlammerEinar Stefánsson
Jan 14, 2003·Archives of Ophthalmology·M Cristina LeskeUNKNOWN Early Manifest Glaucoma Trial Group
Apr 17, 2003·Current Opinion in Ophthalmology·Douglas R Anderson, UNKNOWN Normal Tension Glaucoma Study
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Jaewan ChoiMichael S Kook
Jul 17, 2007·Ophthalmology·M Cristina LeskeUNKNOWN BESs Study Group
Apr 2, 2009·Korean Journal of Ophthalmology : KJO·Soo Geun JoeMichael S Kook
May 29, 2009·Investigative Ophthalmology & Visual Science·Kyung Rim SungMichael S Kook
Feb 19, 2010·Investigative Ophthalmology & Visual Science·Yingfeng ZhengTin Aung
Dec 22, 2010·Indian Journal of Ophthalmology·Douglas R Anderson
Jan 25, 2011·American Journal of Ophthalmology·Theodore KrupinUNKNOWN Low-Pressure Glaucoma Study Group
Mar 2, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Yoshihiko OkumuraKazuo Tsubota
Jul 28, 2012·American Journal of Ophthalmology·Carlos Gustavo De MoraesUNKNOWN Low-pressure Glaucoma Treatment Study Group
May 20, 2014·Survey of Ophthalmology·Hyun-Kyung Cho, Changwon Kee
May 30, 2014·Ophthalmology·Mary E CharlsonJeffrey M Liebmann
May 20, 2015·European Journal of Ophthalmology·Elif ErdemGeorge L Spaeth

❮ Previous
Next ❯

Citations

Mar 12, 2019·Hypertension·Marc Leeman, Philippe Kestelyn
Dec 16, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Anna Ym WangKirstan A Vessey
Jan 3, 2020·Current Opinion in Ophthalmology·Sophia Y Wang, Kuldev Singh
Dec 13, 2018·The EPMA Journal·Tatjana BinggeliKatarzyna Konieczka
Oct 8, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Karin R Pillunat, Lutz E Pillunat

❮ Previous
Next ❯

Software Mentioned

SPSS
EMGT
CNTGS
Humphrey program

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.