Low numbers of blood and salivary natural killer cells are associated with a better response to belimumab in primary Sjögren's syndrome: results of the BELISS study

Arthritis Research & Therapy
Raphaèle SerorXavier Mariette

Abstract

In this study, we sought to address changes in blood lymphocyte subpopulations and labial salivary gland (LSG) inflammation after belimumab treatment in patients with primary Sjögren's syndrome (pSS) and to identify predictors of response to treatment. Sequential blood lymphocyte subsets and LSG biopsies were analysed between week 0 (W0) and W28 in 15 patients with pSS treated with belimumab. Systemic response to treatment was defined as a decrease in the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index score of ≥3 points at W28. After belimumab, we observed a decrease in blood B lymphocytes primarily involving CD27-negative/immunoglobulin D-positive naïve B cells (p=0.008). Lymphocytic sialadenitis (focus score >1) that was present in 12 patients (80.0 %) before belimumab treatment became negative in 5 of them after treatment (p=0.03). The median (interquartile range) LSG B-cell/T-cell ratio decreased from 0.58 (0.5-0.67) to 0.50 (0.5-0.5) (p=0.06). B-cell activating factor (BAFF) staining was detected in 11 (78.6 %) of 14 patients before belimumab treatment compared with 7 (50.0 %) of 14 after belimumab therapy (p=0.10). The median percentage of BAFF-positive cells in foci significantly decreased f...Continue Reading

References

Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Dec 10, 1999·The Journal of Experimental Medicine·F MackayJ L Browning
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Jan 15, 2003·Annals of the Rheumatic Diseases·X MarietteR Kimberly
May 1, 2009·Genes and Immunity·E S EmamianK L Moser
Jun 30, 2009·Annals of the Rheumatic Diseases·Raphaèle SerorUNKNOWN EULAR Sjögren's Task Force
Mar 1, 2012·Journal of Autoimmunity·A G Tzioufas, P G Vlachoyiannopoulos
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·John C HallAntony Rosen
Jul 17, 2013·Nature Reviews. Rheumatology·Gaëtane Nocturne, Xavier Mariette
Jul 26, 2013·Science Translational Medicine·Sylvie RusakiewiczXavier Mariette
Dec 19, 2013·Annals of the Rheumatic Diseases·Xavier MarietteSalvatore De Vita

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Citations

May 18, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ryan L Quock
Mar 3, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Pierre GazeauValérie Devauchelle-Pensec
Jun 12, 2018·Current Opinion in Rheumatology·Gudny Ella ThorlaciusLars Rönnblom
Sep 4, 2018·Expert Review of Clinical Immunology·Iris L A Bodewes, Marjan A Versnel
Feb 17, 2019·Rheumatology·Iris L A BodewesMarie Wahren-Herlenius
Apr 4, 2019·Journal of Cellular Physiology·Arezoo G ShabgahMojgan Mohammadi
Jul 8, 2016·Nature Reviews. Disease Primers·Pilar Brito-ZerónManuel Ramos-Casals
Sep 10, 2019·Rheumatology·Judith A JamesE William St Clair
Jun 18, 2019·Lupus Science & Medicine·Mary K Crow, Lars Ronnblom
Jul 21, 2016·Inflammation and Regeneration·Shingo Nakayamada, Yoshiya Tanaka
Feb 26, 2019·Frontiers in Immunology·Smita Y PatelStephen Jolles
Dec 8, 2015·Arthritis Research & Therapy·Simon J Bowman, Benjamin A Fisher
Jan 19, 2017·Annual Review of Medicine·Clio P Mavragani
Jun 1, 2017·Clinical Reviews in Allergy & Immunology·Kristina SchreiberClaire I Daïen
Jun 9, 2021·Clinical and Experimental Medicine·Simone NegriniFrancesco Puppo
Nov 4, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Bin WangGuixiu Shi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
flow cytometry
biopsy
fluorescence-activated cell-sorting
biopsies

Clinical Trials Mentioned

NCT01160666
NCT01008982

Software Mentioned

SAS

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