Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy.

EBioMedicine
Tamar SoferD. J. Gottlieb

Abstract

Sleep Disordered Breathing (SDB) is associated with a wide range of pathophysiological changes due, in part, to hypoxemia during sleep. We sought to identify gene transcription associations with measures of SDB and hypoxemia during sleep, and study their response to treatment. In two discovery cohorts, Framingham Offspring Study (FOS; N = 571) and the Multi-Ethnic Study of Atherosclerosis (MESA; N = 580), we studied gene expression in peripheral blood mononuclear cells in association with three measures of SDB: Apnea Hypopnea Index (AHI); average oxyhemoglobin saturation (avgO2) during sleep; and minimum oxyhemoglobin saturation (minO2) during sleep. Associated genes were used for analysis of gene expression in the blood of 15 participants with moderate or severe obstructive sleep apnea (OSA) from the Heart Biomarkers In Apnea Treatment (HeartBEAT) trial. These genes were studied pre- and post-treatment (three months) with continuous positive airway pressure (CPAP). We also performed Gene Set Enrichment Analysis (GSEA) on all traits and cohort analyses. Twenty-two genes were associated with SDB traits in both MESA and FOS. Of these, lower expression of CD1D and RAB20 was associated with lower avgO2 in MESA and FOS. CPAP treatme...Continue Reading

Citations

May 21, 2021·Briefings in Bioinformatics·Tamar SoferKent D Taylor

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Datasets Mentioned

BETA
GSE133601

Methods Mentioned

BETA
chip
GTPAses
blood draw
blood draws

Clinical Trials Mentioned

NCT01086800

Software Mentioned

Gene Set Enrichment Analysis ( GSEA )
Enrichment Map
GSEA
multtest R
HeartBEAT
FOS
Cytoscape
MESA
R environment for statistical computing
affy Bioconductor R package

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