Low P16INK4A Expression Associated with High Expression of Cancer Stem Cell Markers Predicts Poor Prognosis in Cervical Cancer after Radiotherapy

International Journal of Molecular Sciences
Hung-Chun FuHong-Yo Kang

Abstract

Previous studies have suggested that cancer stem cells (CSCs) resisted radiotherapy and chemotherapy. P16INK4A is a biomarker for cervical carcinogenesis and reduces proliferation of stem cells. We aimed to investigate the expression and clinical significance of cyclin-dependent kinase inhibitor 2A (P16INK4A), sex determining region Y-box 2 (SOX2), and Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1) in cervical cancer treated with radiotherapy and cervical cell line models. The expressions of P16INK4A, SOX2, and ALDH1A1 were performed by immunohistochemical staining of tumor samples from 139 cervical cancer patients with International Federation of Gynecology and Obstetrics stages Ib to IV. The staining showed high expression in 100, 107, and 13 patients with P16INK4A (>80%), SOX2 (≥10%), and ALDH1A1 (50%), respectively. The high-P16INK4A group had a higher five-year overall survival (OS) rate and disease-free survival (DFS) than the low-P16INK4A group (OS: 62.0% and 35.2%, p = 0.016; DFS: 60.0% and 31.2%, p = 0.002). The low-P16INK4A/high-SOX2 and low-P16INK4A/high-ALDH1A1 groups had a worse five-year OS and DFS rate than the high-P16INK4A/low-SOX2 and high-P16INK4A/low-ALDH1A1 groups, respectively. Depletion of P16INK4A ...Continue Reading

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Citations

Mar 8, 2019·Frontiers in Genetics·Lucy Wanjiku MachariaVivaldo Moura-Neto
Mar 25, 2020·International Journal of Molecular Sciences·Saioa MendazaEsperanza Martín-Sánchez
Nov 7, 2019·Journal of Cellular Biochemistry·Abhijnya Vijayavittal KanugoviSreedhar Subbarao Amere
May 25, 2021·Frontiers in Oncology·Luciana W ZuccheratoPaulo Guilherme O Salles
Feb 4, 2022·Journal of Cancer Research and Clinical Oncology·Irina LarionovaEvgeny Denisov

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Methods Mentioned

BETA
hysterectomy
dissection
X-ray
electrophoresis
enzyme-linked immunosorbent assay
PCR

Software Mentioned

SPSS

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