Low p21 level is necessary for the suppressive effects of micoRNA-31 on glioma cell migration and invasion

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jun PanShizhong Zhang

Abstract

MicroRNAs (miRNAs), a kind of endogenous non-coding RNAs, regulate gene expression through binding to the 3'-untranslational region (UTR) of target messenger RNAs (mRNAs) and act as endogenous agents of RNA interference, resulting in either mRNA degradation or translational repression. MiR-31 has been demonstrated to be associated with the development and progression of glioma. However, the underlying molecular mechanism remains largely unclear. In the present study, we demonstrated that miR-31 only inhibited the cell migration and invasion, as well as the expression of a known miR-31 target oncogene radixin, in U251 glioma cells that expressed low level of p21; however, miR-31 showed no above effects on glioma SHG44 cells that highly expressed p21. Moreover, upregulation of p21 in U251 cells reversed the suppressive effects of miR-31 on the cell migration and invasion, suggesting that low p21 level is necessary for the miR-31-mediated inhibitory effects on glioma. Furthermore, analysis for 35 glioma specimens showed that the expression of radixin was negatively correlated with the miR-31 level in glioma tissues with low p21 expression; however, no such correlation was found in glioma tissues with high p21 level, further suppor...Continue Reading

References

Nov 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·A L GartelA L Tyner
Feb 28, 2002·Current Biology : CB·Eric G Moss
Aug 13, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kalevi J Pulkkanen, Seppo Yla-Herttuala
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
May 24, 2007·Cancer·Sith SathornsumeteeJeremy N Rich
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Amaia LujambioManel Esteller
Jan 30, 2009·Journal of Gastroenterology and Hepatology·Junming GuoYanjun Wang
May 15, 2009·Nature Reviews. Cancer·Tarek Abbas, Anindya Dutta
May 19, 2009·BioFactors·Andrei L Gartel
Jun 16, 2009·Cell·Scott ValastyanRobert A Weinberg
Oct 29, 2010·Cell Cycle·Olga AprelikovaJohn Niederhuber
Dec 12, 2012·International Journal of Cancer. Journal International Du Cancer·Urmo VõsaTarmo Annilo
Nov 2, 2013·World Journal of Stem Cells·Eunhyun ChoiKi-Chul Hwang
Nov 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mehdi H ShahiJavier S Castresana
Jan 9, 2015·Genes & Cancer·Zhifeng NingHao Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.