Low Plasma Cholinesterase Activities are Associated with Deficits in Spatial Orientation, Reduced Ability to Perform Basic Activities of Daily Living, and Low Body Mass Index in Patients with Progressed Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Dominika DingovaAnna Hrabovska

Abstract

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by a central cholinergic deficit. Non-neuronal cholinergic changes are, however, described as well. Here we focused on possible changes in the activity of the plasma cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), in hospitalized AD patients. We analyzed plasma AChE and BChE activities with regards to age, gender, body mass index (BMI), cognitive functions, and ability to perform activities of daily living in AD patients in comparison to healthy subjects. We observed lower AChE activity and trend toward lower BChE activity in AD patients, which both correlated with low BMI. AD patients unable to perform basic activities of daily living (feeding, bathing, dressing, and grooming) showed reduced plasma AChE activities, while worse spatial orientation was linked to lower BChE activities. Three out of four AD patients with the lowest BChE activities died within one year. In conclusion, progressed AD was accompanied by lower plasma AChE activity and trend toward lower BChE activity, which correlated with BMI and deficits in different components of the AD.

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Citations

Jul 10, 2016·Journal of Alzheimer's Disease : JAD·Julien DumurgierChristophe Tzourio
Oct 3, 2017·Rheumatology·Fatma Alibaz-OnerKenneth J Warrington
Aug 26, 2017·BioMed Research International·Mei-Xue DongYou-Dong Wei
Feb 6, 2020·Canadian Journal of Physiology and Pharmacology·Zuzana KilianovaAnna Hrabovska
Aug 21, 2021·Biochemical Genetics·Sliha AwanSyed M Nurulain
Sep 11, 2021·Physiological Research·K SzmicsekováA Hrabovská

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