Low Plasma Hydrogen Sulfide Is Associated with Impaired Renal Function and Cardiac Dysfunction

American Journal of Nephrology
Qing KuangXiaoqiang Ding

Abstract

Chronic kidney disease (CKD) has been proposed to associate with decreased hydrogen sulfide (H2S) level. Nevertheless, the role of H2S in the pathogenesis of CKD has not been fully investigated. Our study aimed to investigate the plasma level of endogenous H2S in patients with different stages of CKD, and to identify the role of H2S in the progression of CKD and its relationship with cardiovascular diseases. A total of 157 non-dialysis CKD patients were recruited in our study, with 37 age- and sex-matched healthy individuals as control. Plasma concentration of H2S was measured with spectrophotometry. Sulfhemoglobin, the integration of H2S and hemoglobin, was characterized and measured by dual wavelength spectrophotometry. Serum levels of homocysteine (Hcy), cardiac troponin T (cTnT), and N-terminal pro B type natriuretic peptide were measured using automated analyzers. Conventional transthoracic echocardiography was performed and left ventricular ejection fraction (LVEF) was analyzed as a sensitive parameter of cardiac dysfunction. The plasma H2S level (μmol/L) in CKD patients was significantly lower than those in healthy controls (7.32 ± 4.02 vs. 14.11 ± 5.24 μmol/L, p < 0.01). Plasma H2S level was positively associated with e...Continue Reading

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Citations

Jan 24, 2019·Journal of Nephrology·Alessandra F PernaDiego Ingrosso
Sep 19, 2019·Antioxidants & Redox Signaling·Fernando Martín BoubetaSara Elizabeth Bari
Jul 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yulu GuXiaoyan Zhang
Dec 29, 2020·Frontiers in Pharmacology·Ebenezeri Erasto NgowiDong-Dong Wu
Aug 10, 2021·Molecular Medicine Reports·Hu ZhangNannan Guo

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