Low plasma levels of calcitonin gene-related peptide in persistent post-traumatic headache attributed to mild traumatic brain injury.

Cephalalgia : an International Journal of Headache
Håkan AshinaHenrik Winther Schytz

Abstract

To investigate the role of calcitonin gene-related peptide (CGRP) in persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI). A total of 100 individuals with persistent PTH attributed to mild TBI and 100 age- and gender-matched healthy controls were enrolled between July 2018 and June 2019. Blood was drawn from the antecubital vein and subsequently analyzed using a validated radioimmunoassay for human CGRP. Measurements were performed on coded samples by a board-certified laboratory technician who was blind to clinical information. CGRP plasma levels were lower in subjects with persistent PTH (mean, 75.8 pmol/L; SD, 26.4 pmol/L), compared with age- and gender-matched healthy controls (mean, 88.0 pmol/L; SD, 34.1 pmol/L) (p = 0.04). No correlation was found of CGRP plasma levels with monthly headache days (r = -0.11; p = 0.27), monthly migraine-like days (r = 0.15; p = 0.13), headache quality (r = -0.14; p = 0.15), or a chronic migraine-like headache phenotype (r = -0.02; p = 0.85). CGRP plasma measurements are unlikely a feasible blood-based biomarker of persistent PTH. Future studies should assess whether CGRP plasma measurements can be used to predict development of persistent PTH.

References

Jun 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation·S ValdemarssonR Ekman
Sep 1, 1948·Archives of Neurology and Psychiatry·H A SHENKINS S KETY
Aug 14, 2008·JAMA : the Journal of the American Medical Association·Devi E Nampiaparampil
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Mar 20, 2016·Cephalalgia : an International Journal of Headache·Song GuoMessoud Ashina
Feb 25, 2017·Current Opinion in Neurology·César RamónJulio Pascual
Oct 31, 2017·Cephalalgia : an International Journal of Headache·Alejandro Labastida-RamírezAntoinette MaassenVanDenBrink
May 9, 2018·Headache·Sylvia Lucas, Andrew H Ahn
Jul 15, 2018·The Journal of Headache and Pain·Mi Ji LeeChin-Sang Chung
Mar 12, 2019·Cephalalgia : an International Journal of Headache·Agneta SnoerMessoud Ashina
Jun 5, 2019·Lancet Neurology·Messoud AshinaMichael A Moskowitz
Sep 19, 2019·Nature Reviews. Neurology·Håkan AshinaDavid W Dodick
Sep 26, 2019·Cephalalgia : an International Journal of Headache·Edita NavratilovaFrank Porreca
Feb 28, 2020·Cephalalgia : an International Journal of Headache·Håkan AshinaHenrik Winther Schytz

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Methods Mentioned

BETA
blood drawn

Clinical Trials Mentioned

NCT03791515

Software Mentioned

SPSS Statistics

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.