Low plasma renin activity and high aldosterone/renin ratio are associated with untreated isolated systolic hypertension

Blood Pressure
Mine DurukanSule Korkmaz

Abstract

Isolated systolic hypertension (ISH) is generally encountered in elderly patients and there are scarce data regarding the renin-angiotensin-aldosterone system (RAAS) activity in patients with ISH. We aimed to determine the plasma renin activity (PRA), plasma aldosterone levels (PAL) and aldosterone/PRA ratio (PAL/PRA) in patients (age >50 years) with ISH and to compare these values with patients with essential hypertension (EH) as well as subjects with normal blood pressure values (control) who have similar age and cardiovascular risk profile. Consecutively, 42 untreated ISH patients, 30 patients with EH and 29 normal subjects were included in the study. Parameters were presented as median (interquartile range). There were no significant differences regarding age, gender and other cardiovascular risk factors among groups. As expected, systolic, diastolic blood pressure and pulse pressure values were significantly different among groups. Besides, PRA values were found to be significantly lower in patients with ISH (0.4 [0.2-1.1] ng/ml/h) compared with the EH (0.95 [0.5-2.6] ng/ml/h, p =0.024) and control (1.3 [0.7-2.1] ng/ml/h, p =0.001) groups. Although, PAL were similar among groups, PAL/PRA ratio was significantly higher in I...Continue Reading

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Citations

Jan 24, 2018·American Journal of Physiology. Renal Physiology·Lauren G DoumaMichelle L Gumz
Nov 15, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lauren G DoumaMichelle L Gumz
Feb 14, 2019·American Journal of Physiology. Renal Physiology·Abdel AlliMichelle L Gumz
Sep 25, 2016·Physiological Genomics·Niranjana NatarajanJennifer L Pluznick

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