Abstract
Isolated systolic hypertension (ISH) is generally encountered in elderly patients and there are scarce data regarding the renin-angiotensin-aldosterone system (RAAS) activity in patients with ISH. We aimed to determine the plasma renin activity (PRA), plasma aldosterone levels (PAL) and aldosterone/PRA ratio (PAL/PRA) in patients (age >50 years) with ISH and to compare these values with patients with essential hypertension (EH) as well as subjects with normal blood pressure values (control) who have similar age and cardiovascular risk profile. Consecutively, 42 untreated ISH patients, 30 patients with EH and 29 normal subjects were included in the study. Parameters were presented as median (interquartile range). There were no significant differences regarding age, gender and other cardiovascular risk factors among groups. As expected, systolic, diastolic blood pressure and pulse pressure values were significantly different among groups. Besides, PRA values were found to be significantly lower in patients with ISH (0.4 [0.2-1.1] ng/ml/h) compared with the EH (0.95 [0.5-2.6] ng/ml/h, p =0.024) and control (1.3 [0.7-2.1] ng/ml/h, p =0.001) groups. Although, PAL were similar among groups, PAL/PRA ratio was significantly higher in I...Continue Reading
References
Jun 26, 1991·JAMA : the Journal of the American Medical Association
Nov 1, 1981·Archives of Internal Medicine·K HiramatsuT Izumiyama
Sep 23, 1997·Lancet·J A StaessenA Zanchetti
Jun 17, 1999·American Journal of Hypertension·J HeP K Whelton
Sep 14, 1999·Journal of Human Hypertension·L RamsayG Russell
Sep 18, 1999·Hypertension·M O'Rourke, E D Frohlich
Sep 12, 2000·Current Hypertension Reports·D DuprezD L Clement
Mar 13, 2001·Hypertension·A H El-GharbawyT A Kotchen
Feb 28, 2002·JAMA : the Journal of the American Medical Association·Ramachandran S VasanDaniel Levy
Sep 24, 2002·JAMA : the Journal of the American Medical Association·Sverre E KjeldsenUNKNOWN LIFE (Losartan Intervention for Endpoint Reduction) Study Group
Nov 27, 2002·Circulation·Patrick LacolleyMichel Safar
Jan 9, 2003·American Journal of Hypertension·Bernhard M W Schmidt, Roland E Schmieder
Apr 19, 2003·Hypertension·William B WhiteMichael A Weber
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jul 2, 2004·The New England Journal of Medicine·Ramachandran S VasanDaniel Levy
Oct 14, 2004·Journal of Hypertension·Ivar K EideNils P Lilledahl
Nov 5, 2004·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Azra Mahmud, John Feely
Jul 5, 2005·Journal of Molecular and Cellular Cardiology·Johnny A NehmePaul Milliez
Jun 15, 2007·Journal of Hypertension·Sungha ParkNamsik Chung
Aug 24, 2007·The New England Journal of Medicine·Aram V Chobanian
Jun 3, 2009·Annals of Internal Medicine·James R SowersMurray Epstein
Jun 27, 2009·Clinics in Geriatric Medicine·Maha A Mohamed, Matthew R Weir
Sep 1, 2007·Journal of the American Society of Hypertension : JASH·Edward G Lakatta
May 8, 2010·Journal of the American College of Cardiology·Andreas TomaschitzHarald Dobnig
Aug 24, 2010·Vascular Health and Risk Management·Philip A Kithas, Mark A Supiano
Citations
Jul 24, 2013·Clinical Science·Renata LibiantoElif I Ekinci
Jan 24, 2018·American Journal of Physiology. Renal Physiology·Lauren G DoumaMichelle L Gumz
Nov 15, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lauren G DoumaMichelle L Gumz
Feb 14, 2019·American Journal of Physiology. Renal Physiology·Abdel AlliMichelle L Gumz
Sep 25, 2016·Physiological Genomics·Niranjana NatarajanJennifer L Pluznick