Low postoperative nonstimulated thyroglobulin as a criterion for the indication of low radioiodine activity in patients with papillary thyroid cancer of intermediate risk 'with higher risk features'

Clinical Endocrinology
Pedro Weslley S RosárioMaria Regina Calsolari

Abstract

This study evaluated low-activity (131) I therapy in patients with papillary thyroid carcinoma (PTC) of intermediate risk 'with higher risk features' who had low nonstimulated thyroglobulin (Tg) after thyroidectomy. This was a prospective study including 102 patients with tumours >1 cm and aggressive histology; and/or >3 positive lymph node (LN) or LN >1·5 cm or exhibiting macroscopic extracapsular extension, and clinically apparent (cN1); and/or a combination of a tumour >4 cm, microscopic extrathyroidal extension and LN metastases (cN1). After thyroidectomy, all patients had nonstimulated Tg < 0·3 ng/ml and negative antithyroglobulin antibodies (TgAb) and neck ultrasonography (US). The patients were treated with a low activity of (131) I (1110 or 1850 MBq). Post-therapy whole-body scanning (RxWBS) showed ectopic uptake in four patients. When evaluated 12 months after (131) I therapy, nonstimulated Tg ≤ 0·2 ng/ml with negative TgAb and US, defined as excellent response to initial therapy, was achieved in 101 patients (99%). Only one patient with positive initial RxWBS had structural disease. During follow-up, four patients (4%) relapsed, including LN metastases in two, pulmonary metastases in one, and elevated Tg in one. The o...Continue Reading

References

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Jan 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Cosimo DuranteUNKNOWN PTC Study Group
Nov 20, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Pedro W RosárioMaria Regina Calsolari
Dec 20, 2013·Clinical Endocrinology·Pedro Weslley RosarioMaria Regina Calsolari
Mar 25, 2014·European Journal of Endocrinology·Charlotte Lepoutre-LusseyLaurence Leenhardt
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Jul 3, 2015·Thyroid : Official Journal of the American Thyroid Association·Gi Hyeon SeoSun Wook Kim
Oct 28, 2015·Endocrine-related Cancer·Gabriela Franco MourãoMaria Regina Calsolari

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Citations

Mar 27, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tian TianBin Liu
Aug 25, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Luca GiovanellaPierpaolo Trimboli
Jan 23, 2020·Thyroid : Official Journal of the American Thyroid Association·Lina LiuBin Liu

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