Low Postoperative Platelet Counts Are Associated with Major Morbidity and Inferior Survival in Adult Recipients of Orthotopic Liver Transplantation.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Iakovos AmygdalosGeorg Lurje

Abstract

Platelets (PLT) play an essential functional role in cellular injury and liver regeneration following partial hepatectomy and orthotopic liver transplantation (OLT). Here, we investigated the association of postoperative PLT counts with short- and long-term outcomes in adult OLT recipients. Three hundred consecutive patients from our prospective OLT database were analyzed retrospectively (May 2010-November 2017). Ninety-day post-OLT complications were graded using the Clavien-Dindo (CD) classification and quantified by the comprehensive complication index (CCI). To determine the prognostic accuracy of PLT counts, the area under the receiver operating characteristic curve (AUROC) was calculated for major complications (CD ≥ 3b). Parametric and non-parametric tests were applied for subgroup analyses. Uni- and multivariable logistic regression analyses were performed to identify risk factors for major complications. Graft and patient survival were analyzed using the Kaplan-Meier method as well as uni- and multivariable Cox regression analyses. Postoperative day 6 PLT counts < 70 × 109/L (POD6-70) were identified as the best cutoff for predicting major complications (AUROC = 0.7; p < 0.001; Youden index 0.317). The stratification o...Continue Reading

References

Jul 1, 1968·Archives of Surgery·D E HutchisonT E Starzl
Mar 30, 1999·Transplantation·M A ChatzipetrouA G Tzakis
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Matthias H F Klinger, Wolfgang Jelkmann
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S FengR M Merion
Apr 8, 2006·Science·Mickael LesurtelPierre-Alain Clavien
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonio NocitoPierre-Alain Clavien
Mar 4, 2008·World Journal of Surgery·Soichiro MurataNobuhiro Ohkohchi
Mar 12, 2008·Alimentary Pharmacology & Therapeutics·P WittersD Cassiman
Apr 25, 2008·Journal of Hepatology·Nezam AfdhalRafael Esteban
Jun 27, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ilona T A PereboomRobert J Porte
Oct 24, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A RanaJ C Emond
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Mar 18, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas E Starzl, John J Fung
Apr 24, 2010·Seminars in Thrombosis and Hemostasis·Ton Lisman, Robert J Porte
Aug 3, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kim M OlthoffJason D Christie
Jul 25, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A E BraatUNKNOWN European Liver and Intestine Transplant Association (ELITA) and Eurotransplant Liver Intestine Advisory Committee (ELIAC)
Jun 4, 2013·Annals of Surgery·Ksenija SlankamenacPierre-Alain Clavien
Oct 15, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mickaël LesurtelPierre-Alain Clavien
Jan 8, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Elena RangelovaMarco Del Chiaro
Apr 1, 2016·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Anne AndertMaximilian Schmeding
Jul 19, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Pamecha ViniyendraKumar Vaibhaw
Aug 23, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M KnaakN Selzner
Sep 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SchlegelP Dutkowski
Dec 20, 2016·Clinical Transplantation·Kazuhiro TakahashiMarwan S Abouljoud
Jun 3, 2017·Langenbeck's Archives of Surgery·Jill GwiasdaAlexander Kaltenborn
Jun 13, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Kazuhiro TakahashiGabriel T Schnickel
Apr 11, 2018·World Journal of Gastroenterology : WJG·Kazuhiro TakahashiNobuhiro Ohkohchi
Aug 12, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Zoltan CziganyGeorg Lurje
Aug 22, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Zoltan CziganyGeorg Lurje
Oct 3, 2018·Annals of Surgery·Roxane D StaigerPierre-Alain Clavien

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver International : Official Journal of the International Association for the Study of the Liver
Hye-Mee KwonGyu-Sam Hwang
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Alessandro CucchettiAntonio Daniele Pinna
© 2021 Meta ULC. All rights reserved