Low-Pressure Flow Chemistry of CuAAC Click Reaction Catalyzed by Nanoporous AuCu Membrane

ACS Applied Materials & Interfaces
Jiangwei WenXiao-Min Lin

Abstract

Click chemistry has been widely used in bioconjugation, polymer synthesis, and the development of new anticancer drugs. Here, we report a nanoporous membrane made of AuCu alloy nanowires, which can effectively catalyze copper(I)-catalyzed 1,3-dipolar cycloaddition between azide and terminal alkyne (CuAAC) in flow condition with pressure less than one bar. Comparison studies of the nanowires before and after the reaction using X-ray photoelectron spectroscopy reveal Cu(0) and Cu(I) are main species that promote the reaction. This simple strategy can be used to synthesize a variety of compounds with triazole linkage and extended to gram level chemical production.

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Citations

Oct 22, 2019·Macromolecular Rapid Communications·Steve NeumannWolfgang H Binder
Aug 21, 2020·Future Medicinal Chemistry·Enol LópezJesús Alcázar
Jul 15, 2020·ChemSusChem·Jorge García-LacunaJavier Pérez-Castells
Jun 18, 2021·Beilstein Journal of Organic Chemistry·Guido GambacortaIan R Baxendale
Nov 27, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Chuan HeAndrew V Teplyakov

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