Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration

Journal of Alzheimer's Disease : JAD
Kasper KatiskoEino Solje

Abstract

Several studies have reported reduced risk of cancer in patients with Alzheimer's disease (AD) or Parkinson's disease. The relationship between cancer and frontotemporal lobar degeneration (FTLD) has not been previously reported. Here, our aim was to evaluate the occurrence of cancer in Finnish FTLD patients with a high proportion of C9ORF72 repeat expansion carriers in comparison to age- and sex-matched group of AD patients and control subjects classified as not cognitively impaired (NCI). The prevalence of cancer was 9.7% in FTLD, 18.7% in AD, and 17.4% in NCI (FTLD versus AD p = 0.012, FTLD versus NCI p = 0.029) groups. No differences were observed between C9ORF72 repeat expansion carriers and non-carriers inside the FTLD group. To our knowledge, this is the first study showing significantly lower prevalence of cancer in FTLD patients compared to patients with AD or NCI subjects. Our data suggest an inverse association between neurodegeneration and cancer and that FTLD-specific mechanisms may underlie the especially strong inverse association observed in this study.

References

Mar 7, 2002·Epidemiology·Alexis ElbazWalter A Rocca
Jan 15, 2003·The Journal of School Health·UNKNOWN Office on Smoking and Health, Division of Adolescent and School Health National Center for Chronic Disease Prevention and He
Mar 9, 2005·Neurology·C M RoeJ C Morris
Jun 15, 2007·Cancer Causes & Control : CCC·Jane A DriverGiancarlo Logroscino
Dec 4, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J KrügerA M Remes
Jun 13, 2009·Current Alzheimer Research·M I BehrensC M Roe
Dec 25, 2009·Neurology·C M RoeJ C Morris
Jan 8, 2010·Cancer Causes & Control : CCC·Archna BajajEva S Schernhammer
Apr 24, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A-L KaivorinneA M Remes
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Mar 14, 2012·BMJ : British Medical Journal·Jane A DriverPhillip A Wolf
Oct 19, 2012·Neuroepidemiology·Shuo-Ming OuShuu-Jiun Wang
Jun 20, 2014·Lancet Neurology·Raffaele FerrariParastoo Momeni
Jul 13, 2014·Journal of Cancer Research and Clinical Oncology·Hai-bin ShiGuo-Jun Chen
Jul 15, 2016·Science Translational Medicine·Aaron BurberryKevin Eggan

❮ Previous
Next ❯

Citations

Nov 18, 2018·Muscle & Nerve·Miguel Tábuas-PereiraIsabel Santana
Oct 16, 2018·Journal of Alzheimer's Disease : JAD·Kasper KatiskoAnne M Remes
Jun 20, 2020·Neurodegenerative Disease Management·Dorit HoffmannAnnakaisa Haapasalo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.