Low prevalence of infection by HTLV-I in populations at risk for HIV in Djibouti

Annales De L'Institut Pasteur. Virology
E FoxG Rodier

Abstract

In order to determine whether HTLV-I (a recently discovered retrovirus causing T-cell leukaemias and lymphomas, as well as tropical spastic paraparesis) was present in Djibouti in 1988, we investigated 576 subjects belonging to various groups at risk of acquiring HIV, a related retrovirus transmitted analogously to HTLV-I. Sera were screened by a commercial agglutination assay and confirmation of repeatedly reactive sera was performed by specific Western blot analysis. Four sera were strongly positive for HTLV-I by Western blotting, while one serum displayed equivocal reactivity. All positive sera came from young women who engaged in prostitution. This accounted for an HTLV-I seropositivity rate of 0.7% (95% CI, 0.03-1.4%) in the total study population and 1.2% (95% CI, 0.02-2.4%) in the population engaged in prostitution. We concluded that in Djibouti in June 1988, HTLV-I was present but that the prevalence of infection in high risk individuals was very low.

References

Jan 28, 1988·The New England Journal of Medicine·G Y MinamotoJ Hoffer
Jan 28, 1988·The New England Journal of Medicine·S Broder
Sep 28, 1984·Science·W SaxingerR Jacobson
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo

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Citations

May 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·N T ConstantineP Marx
Oct 1, 1991·Epidemiology and Infection·N T ConstantineD M Watts

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