Low prevalence of microsatellite instability in interval gastric cancers

Digestive Diseases and Sciences
Hong Seok ChoiHye Seung Han

Abstract

Esophagogastroduodenoscopy (EGD) is recommended at 2-year intervals in countries with a high prevalence of gastric cancer. The aim of this study was to determine whether interval gastric cancers that develop within 2 years of a previous complete screening are associated with microsatellite instability (MSI). Newly diagnosed gastric cancer patients who had undergone gastrectomy were included. Of these 459 patients, 177 were classified as interval gastric cancer since they were diagnosed within 2 years of a previous EGD. Noninterval gastric cancer patients were subclassified into 65 patients who underwent previous EGD between the past 2 and 10 years and 217 patients without EGD during the last 10 years. Analysis for MSI was conducted using two mononucleotide and three dinucleotide markers. MSI was found more frequently in noninterval gastric cancers than in interval gastric cancers (p = 0.009). Interval gastric cancers were associated with a higher prevalence of early gastric cancer (p = 0.006), smaller size (p < 0.001), and lower TNM stages (p = 0.006). On logistic regression analysis, noninterval gastric cancers were related to MSI (p = 0.010) and larger size (≥4 cm) (p = 0.009). Subjects with interval gastric cancer showed bet...Continue Reading

References

Dec 1, 1996·The Journal of Pathology·G TamuraR Satodate
Jun 1, 1997·The Journal of Pathology·G BuonsantiG N Ranzani
Jun 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hye Seung LeeWoo Ho Kim
Jun 30, 2004·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Leizhen ZhengKeping Xie
Aug 13, 2005·World Journal of Gastroenterology : WJG·Ping LiuDao-Fu Zhang
Sep 2, 2005·The Korean Journal of Internal Medicine·Won Hyuk ChoeJae J Kim
Apr 18, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·James P Hamilton, Stephen J Meltzer
Jun 9, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L OttiniA Russo
Nov 8, 2006·Gastroenterology·Mandeep S SawhneyJohn H Bond
Apr 17, 2009·European Journal of Gastroenterology & Hepatology·Su Youn NamYoung-Woo Kim
Oct 1, 2010·Annals of Surgical Oncology·Kay Washington
Feb 22, 2011·Journal of Gastroenterology and Hepatology·Hyunki KimHoguen Kim
Jul 21, 2011·Digestive Diseases and Sciences·Sun-Young LeeJohn M Carethers
Mar 1, 2012·International Journal of Cancer. Journal International Du Cancer·Su Jin ChungHyun Chae Jung

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