Low proliferative rate of invasive node-negative breast cancer predicts for a favorable outcome: a prospective evaluation of 669 patients

Clinical Breast Cancer
S JonesC Rietz

Abstract

This study was designed to compare outcome in terms of disease-free survival (DFS) in women with histologically negative axillary lymph nodes and documented low proliferative rate cancer to other well-defined prognostic factors including type of adjuvant treatment. Between 1988 and 1998, we studied 669 patients with invasive node-negative breast cancer up to 5 cm in size and low proliferative rate measured by flow cytometry to determine S-phase fraction (SPF) or by histochemistry (Ki67/MIB1). At a median follow-up of 53 months, 5-year DFS for the entire group was 94% and did not differ significantly by type of systemic adjuvant treatment: none (133 patients, 95% DFS), tamoxifen (441 patients, 94% DFS), or chemotherapy with doxorubicin and cyclophosphamide (95 patients, 92% DFS). In a multivariate prognostic factor analysis, only tumor size was significant; 5-year DFS was 96% for T1N0 cancer versus 89% for T2N0 cancer (P = 0.01). We have prospectively confirmed that a low rate of proliferation as measured by SPF or MIB1 determination confers an excellent prognosis in invasive node-negative breast cancer up to 5 cm in size, regardless of adjuvant treatment.

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Citations

Dec 8, 2015·The Veterinary Journal·Raquel Sánchez-CéspedesJuana Martín de Las Mulas
Jun 3, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Julie M WuAllan D Hess
Aug 22, 2012·Oncology·Eramah ErmiahYrjö Collan
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Megan M GarrityUNKNOWN North Central Cancer Treatment Group
Dec 5, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mikael RailoStig Nordling
Nov 10, 2005·Proceedings·Marvin J StoneC Allen Stringer
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Fatemeh Homaei ShandizAlireza Pasdar
Jun 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charles DumontetJohn C Reed

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