Low protein alimentation normalizes renal haemodynamic response to acute protein ingestion in type 1 diabetic children

European Journal of Clinical Investigation
P CastellinoC Giordano

Abstract

The effect of an acute protein load (2 g kg-1 bodyweight [BW]) was studied in nine type 1 diabetic children. Patients were maintained on two different dietary regimens. In study one, patients were on a high protein diet providing from 2.7 to 1.8 g of protein/kg of BW per day. In study two, patients were reevaluated after three weeks of a diet providing from 1.0 to 1.2 g kg-1 of BW per day of protein. In study one (High Protein Diet), we failed to observe any rise in GFR and RPF following the protein meal (137 +/- 21 basal vs. 110 +/- 14 and 472 +/- 93 basal vs. 494 +/- 93 ml/1.73 m2 of SA min-1 at 60 min. This is in contrast with results from seven age matched controls consuming a free diet, which showed a significant rise in both GFR and RPF. In study two (low protein diet), basal GFR was significantly reduced. However after the protein load, both GFR (92 +/- 11 vs. 126 +/- 18 ml/1.73 m2 of SA min-1) and RPF (467 +/- 83 vs. 705 +/- 102 ml/1.73 m2 min-1) rose significantly (P less than 0.05 vs. basal). The data indicate that: 1. short term protein restriction reduces significantly GFR in type 1 diabetic children; 2. diabetic children maintained on an high protein intake show an altered haemodynamic response to protein ingestion...Continue Reading

References

Apr 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J UrangaE del Castillo
Aug 1, 1985·The Journal of Clinical Investigation·S AndersonB M Brenner
Apr 1, 1986·Kidney International·P M ter WeeA J Donker
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R ZatzB M Brenner
Nov 1, 1984·The American Journal of Medicine·J P BoschS Glabman
Dec 1, 1983·The American Journal of Medicine·J P BoschS Glabman
Jul 12, 1984·The New England Journal of Medicine·C E Mogensen, C K Christensen
Mar 1, 1981·Kidney International·T H HostetterB M Brenner
Oct 1, 1955·The Journal of Clinical Investigation·M WALSERJ ORLOFF

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