PMID: 2494959Apr 1, 1989Paper

Low protein diets improve survival from peritonitis in guinea pigs

Annals of Surgery
M D PeckP W Miskell

Abstract

Enteral diets with different protein content were tested to determine their effect on outcome in a model of protracted bacterial peritonitis. Hartley guinea pigs were provided with gastrostomies, and 1 week later, osmotic pumps were implanted into the peritoneal cavity to allow for continuous release of live bacteria over the course of 1 week. Three days after pump implantation, the animals began receiving isocaloric enteral diets that contained 5%, 10%, 15%, or 20% of total calories as protein. After 2 weeks of observation, the survivors were killed. All animals lost weight during the 2-weeks period, but there was no difference in weight lost. Nitrogen balance correlated with dietary protein. The mortality rate was significantly higher in the groups that received 15% and 20% of total calories compared with the group that received 5% (p less than 0.05). Although dietary protein in the 5% group was insufficient for meeting the nutritional needs of the animal, survival was best in this group. Possible explanations are that protein restriction in this model may either augment host defence or impair bacterial virulence.

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Citations

Nov 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·R F Grimble
Jul 17, 1998·Journal of the American Dietetic Association·C J KleinC E Wiles
Jul 31, 1998·Nutrition·R F Grimble
May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·M E Keith, K N Jeejeebhoy
Jan 1, 1990·Nutrition Research Reviews·R F Grimble
Aug 23, 2007·Der Internist·K G KreymannR F Meier
Jul 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·P Clouva-MolyvdasJ W Alexander
May 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·S J GonceP W Miskell
Jul 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·M D Peck, J W Alexander
Nov 2, 2001·JPEN. Journal of Parenteral and Enteral Nutrition·W KangK Maekawa
Oct 1, 1990·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R H Bower
Jul 20, 2007·The Proceedings of the Nutrition Society·Mike Stroud
Mar 9, 2007·The Proceedings of the Nutrition Society·Jeremy Powell-Tuck
Jul 1, 1994·Current Problems in Surgery·W W Souba

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