Low pulse pressure is an independent predictor of mortality and morbidity in non ischaemic, but not in ischaemic advanced heart failure patients

International Journal of Cardiology
Colin J PetrieDirk J van Veldhuisen

Abstract

In patients with atherosclerotic disease, a high pulse pressure is an important predictor of cardiovascular events. However, in patients with chronic heart failure (CHF) a low pulse pressure is related to worse outcome, although no distinction was made between ischaemic and non ischaemic heart failure. We therefore aimed to compare the prognostic value of pulse pressure (PP) between those with ischaemic and non ischaemic advanced heart failure. Pulse pressure was analysed for its effect on mortality, adjusting for other modifiers of risk, using Cox proportional hazards regression analysis of data collected from 1901 patients with NYHA class III or IV heart failure (mean age 65 years, mean ejection fraction 26%). In ischaemic heart failure (n=1118), low mean arterial pressure (MAP) was an independent predictor of overall mortality (Hazard Ratio (HR) 0.88 per 10 mm Hg; p=0.04), while pulse pressure was not. In contrast, in non ischaemic heart failure (n=783), a low pulse pressure was an independent predictor of overall mortality (HR 0.84 per 10 mm Hg; p=0.036), while mean arterial pressure was not. In addition, higher NYHA class and lower pulse pressure (HR 0.87 per 10 mm Hg; p=0.002) were the only independent predictors for firs...Continue Reading

References

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Citations

Sep 22, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Colin J PetrieHenry J Dargie
Jan 27, 2015·European Heart Journal·Colette E JacksonUNKNOWN Meta-Analysis Global Group in Chronic Heart Failure MAGGIC
Sep 29, 2011·Archives of Cardiovascular Diseases·Ayman El-MenyarJassim Al Suwaidi
Dec 22, 2017·Clinical and Experimental Hypertension : CHE·Colin J PetrieAdriaan A Voors
Dec 10, 2019·ESC Heart Failure·Stefano BonapaceUNKNOWN European Society of Cardiology Heart Failure Long-Term Registry Investigators group
Apr 2, 2014·Journal of Cardiovascular Medicine·Colin J PetrieAdriaan A Voors

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