Low rate of glutamic acid decarboxylase 65 (GAD-65) antibodies in chronic epilepsy.

Seizure : the Journal of the British Epilepsy Association
Etsegenet TizazuEric Lancaster

Abstract

Autoantibodies against glutamic acid decarboxylase 65 (GAD-65) have been identified in patients with chronic epilepsy. In this study, we ask (1) what is the frequency of GAD-65 antibodies in chronic epilepsy? (2) what is the frequency and type of epilepsy in individuals with GAD-65 antibodies? For cohort 1, serum samples of patients with epilepsy (without type I diabetes) were obtained from our biobank. Samples were tested for GAD-65 antibodies using a cell-based assay and confirmed by immunohistochemistry. For cohort 2, patients with positive GAD-65 antibodies were identified and their medical records were reviewed for the presence and characteristics of epilepsy. Cohort 1 included 270 patients, of which 53% were women; median age was 47 years; median duration of epilepsy was 16 years. Epilepsy was focal in 87% (temporal lobe in 20%), and drug-resistant in 45%. GAD-65 antibodies were present in two out of 270 cases (0.7%) and zero controls. Cohort 2 consisted of 23 patients with known GAD-65 antibodies, of which ten had epilepsy (43%). Of these, 80% were women with a median age of 40 years and a median duration of epilepsy of 18 years. All ten patients had focal epilepsy, nine had temporal lobe epilepsy, and seven were drug re...Continue Reading

References

Apr 7, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Luca ErrichielloPasquale Striano
Feb 23, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M FalipF Graus
May 20, 2014·Seizure : the Journal of the British Epilepsy Association·James B LillekerRajiv Mohanraj
May 24, 2014·Annals of Neurology·Liane DahmHannelore Ehrenreich
Jul 15, 2015·BMJ Open Diabetes Research & Care·Elin Pettersen SørgjerdValdemar Grill
Jan 13, 2016·Journal of Clinical Neurology·Eric Lancaster
Oct 28, 2017·Neurology. Neuroimmunology and Neuroinflammation·Lindsey McCrackenEric Lancaster
Feb 13, 2018·Epilepsy & Behavior : E&B·Ahmad DaifShasha Wu
May 14, 2018·Seizure : the Journal of the British Epilepsy Association·Pablo Cabezudo-GarcíaPedro J Serrano-Castro

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