Low rates of antiretroviral therapy among HIV-infected patients with chronic kidney disease

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Andy I ChoiA M O'Hare

Abstract

It is unknown whether chronic kidney disease (CKD) influences receipt of highly active antiretroviral therapy (HAART) among patients with the human immunodeficiency virus (HIV) and whether prescription practices contribute to excess mortality. We conducted a retrospective observational study involving HIV-infected patients with established indications for HAART and an outpatient serum creatinine level measured in the Veterans Affairs health care system. Patients were followed up for the outcomes of HAART exposure (percentage of follow-up time treated with HAART), inadequate dose adjustment of renally eliminated antiretroviral medications, and time to death. A total of 1041 patients (8.5%) had CKD, defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2). Compared with patients with an eGFR >or=60 mL/min/1.73 m(2), HAART exposure was 14% less (95% confidence interval [CI], 2%-24% less), 24% less (95% CI, 4% more to 45% less), 64% less (95% CI, 38%-79% less), and 49% less (95% CI, 32%-61% less) in patients who had an eGFR of 30-59 mL/min/1.73 m(2), 15-29 mL/min/1.73 m(2), and <15 mL/min/1.73 m(2) (and were not receiving dialysis) and in patients receiving long-term dialysis, respectively. At study entry, 15....Continue Reading

References

Jan 30, 1992·Statistics in Medicine·L S FreedmanA Schatzkin
Feb 1, 1995·American Journal of Epidemiology·S G FisherF Davis
Jun 1, 1996·Annals of Internal Medicine·M J Glesby, D R Hoover
Jul 2, 1997·JAMA : the Journal of the American Medical Association·D BangsbergA R Moss
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N SinghM M Wagener
Jan 27, 2000·JAMA : the Journal of the American Medical Association·C C CarpenterP A Volberding
Mar 17, 2001·Journal of General Internal Medicine·R L CookJ Conigliaro
Dec 26, 2001·Journal of Clinical Epidemiology·L BackusL Deyton
Jan 5, 2002·Nihon rinsho. Japanese journal of clinical medicine·K Ohyashiki
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gunter WolfFuad N Ziyadeh
Mar 28, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Richard M SelikMark S Dworkin
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Tejinder S AhujaShilpi Khan
Jul 4, 2002·JAMA : the Journal of the American Medical Association·Mark S SulkowskiDavid L Thomas
Jul 23, 2002·Journal of General Internal Medicine·Amy M KilbourneMaria Rodriguez-Barradas
Oct 16, 2002·Annals of Epidemiology·Diane C CowperDenise M Hynes
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Michael J Ross, Paul E Klotman
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Rudolph A RodriguezPatricia Schoenfeld
May 20, 2003·Kidney International·Lynda Anne SzczechUNKNOWN Adult AIDS Clinical Trial Group Renal Complications Committee
Jun 13, 2003·Medical Care Research and Review : MCRR·Yujing ShenLewis E Kazis
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer N BlanchardJ Tyler Lonergan
Nov 25, 2003·Kidney International·Hassane IzzedineGilbert Deray
Apr 29, 2004·Diabetes Care·Charles Maynard, Michael K Chapko
Aug 26, 2004·Kidney International·Lynda Anne SzczechJonathan A Winston
Nov 10, 2004·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Ann M BorzeckiDan R Berlowitz
Dec 17, 2004·Journal of the American Society of Nephrology : JASN·Ann M O'HareMary-Margaret Chren
May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samir K GuptaLynda A Szczech
Jul 1, 2005·Journal of the American Society of Nephrology : JASN·Elissa J SchwartzPaul E Klotman
Jul 20, 2006·Medical Care·Amy C JusticeKendall Bryant
Sep 13, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julie C ServossGregory K Robbins

❮ Previous
Next ❯

Citations

Feb 11, 2011·Current Infectious Disease Reports·Jayme E Locke, Dorry L Segev
Oct 22, 2013·Current Infectious Disease Reports·Valentina Stosor
Sep 25, 2009·Nature Reviews. Nephrology·Lynda A FrassettoPeter G Stock
Nov 19, 2010·The New England Journal of Medicine·Peter G StockMichelle E Roland
Dec 1, 2011·Sexual Health·Claire NaftalinFrank A Post
Feb 9, 2012·AIDS·Rebecca ScherzerMichael G Shlipak
Jan 28, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael J FischerUNKNOWN VACS Project Team
Jun 29, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michelle M EstrellaStephen J Gange
Jun 8, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michelle M EstrellaLisa P Jacobson
May 18, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Raj K MedapalliChristina M Wyatt
Feb 20, 2009·HIV Medicine·L J CampbellF A Post
Sep 1, 2009·Journal of the American Medical Informatics Association : JAMIA·Lisa I BackusLarry A Mole
May 21, 2010·Clinical Pharmacokinetics·Claudia KasserraThomas Marbury
Feb 19, 2011·HIV Therapy·Michelle M EstrellaMohamed G Atta
Jun 21, 2013·Journal of the International AIDS Society·Rajendra BhimmaUdai Kala
Mar 4, 2015·Open Forum Infectious Diseases·Samir K GuptaUNKNOWN AIDS Clinical Trials Group Study A5224s Team
Feb 2, 2012·Clinical and Experimental Nephrology·Minoru AndoKosaku Nitta
Jan 21, 2011·Kidney International·Joan C TrullasJose M Miro
Aug 17, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andy ChoiMichael G Shlipak
Dec 17, 2009·Advances in Chronic Kidney Disease·Robert C Kalayjian
Apr 24, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fowzia IbrahimUNKNOWN UK Collaborative HIV Cohort (CHIC)/CKD Study Group
Jul 16, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sarah Razzak ChaudharyWolfgang C Winkelmayer
Sep 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory M LucasUNKNOWN HIV Medicine Association of the Infectious Diseases Society of America
Jun 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Il Joon Paik, Donald P Kotler
Dec 17, 2009·Advances in Chronic Kidney Disease·Michelle M Estrella, Derek M Fine
Jun 14, 2017·Seminars in Dialysis·Suzanne M BoyleChristina M Wyatt
Dec 25, 2008·Current Opinion in Infectious Diseases·Frank A Post, Stephen G Holt
Mar 14, 2020·AIDS·Rebecca N Kumar, Valentina Stosor

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