Low recurrence of preexisting extrahepatic malignancies after liver transplantation

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Daniel BentenAnsgar W Lohse

Abstract

The incidence of de novo malignancies is increased in organ transplant recipients, and patients with hepatic carcinomas are at high risk for tumor recurrence after liver transplantation. Data about recurrent cancer after orthotopic liver transplantation (OLT) in patients with a history of nonhepatic malignancy are very limited. We retrospectively analyzed data from 606 adult OLT recipients and identified 37 patients (6.1%) with a preexisting extrahepatic malignancy. In the same group, 43 patients (7.0%) developed de novo cancer. Preexisting malignancies included 26 solid tumors and 11 hematological malignancies, including 7 patients with Budd-Chiari syndrome due to myeloproliferative disorders (MPDs). Patients had been selected for OLT because of the expected good prognosis of their preexisting malignancy. Except for 3 patients, recipients were tumor-free at OLT. The median interval from tumor diagnosis to OLT was 44 months (range, <1-321). After a median follow-up of 66 months post transplantation (range, 4-131), all but 1 recipient with incidental colon carcinoma were free of recurrence. No patient with MPD showed leukemic transformation, whereas a patient with neurofibromatosis experienced growth of skin fibromas. Our data a...Continue Reading

References

Sep 1, 1990·Neurology·E F WijdicksV M Riccardi
Jun 10, 2000·International Journal of Dermatology·M B MillerK Soltani
Jan 11, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S SaigalJ O'Grady
Mar 30, 2002·Transplantation·Parthi SrinivasanNigel Heaton
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christian A MerloJonathan B Orens
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Norman M KnetemanDavid L Bigam
Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J Ignacio HerreroJesús Prieto
Feb 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roberto MarchioliTiziano Barbui
Mar 30, 2005·Ear, Nose, & Throat Journal·Enrique Palacios
Apr 2, 2005·American Journal of Clinical Oncology·William M MendenhallMark T Scarborough
Aug 27, 2005·The New England Journal of Medicine·Stephan BraunKlaus Pantel
Oct 8, 2005·Seminars in Hematology·Guido Finazzi, Claire Harrison
Nov 16, 2005·Transplantation·Joachim AndrassyMarkus Guba
Nov 22, 2005·Journal of Surgical Oncology·Jang I MoonAndreas G Tzakis
Apr 6, 2006·Virchows Archiv : an International Journal of Pathology·Florian GrabellusKurt W Schmid
Sep 16, 2006·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Oct 20, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Richard B Freeman
Jan 30, 2007·Nature Clinical Practice. Oncology·Klaus Pantel, Catherine Alix-Panabières

❮ Previous
Next ❯

Citations

Nov 26, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Daniel BentenMartina Sterneck
Sep 11, 2009·Transplantation·Ashokkumar JainMark Orloff
Jul 30, 2011·World Journal of Gastroenterology : WJG·Timothée NoterdaemeOlivier Detry
Aug 21, 2012·Transplantation Reviews·Josep M CampistolUNKNOWN ATOS Working Group
Oct 29, 2011·Clinics in Liver Disease·Theresa R HarringJohn A Goss
Mar 5, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·José Ruiz PardoPascual Parrilla Paricio
Aug 14, 2009·La Presse médicale·Monika HurtovaChristophe Duvoux
Mar 5, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Andrej PotthoffMatthias J Bahr
Jul 7, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Eric Chak, Sammy Saab
Jan 13, 2018·Journal of Oncology Practice·Philip J Bierman
Aug 14, 2015·World Journal of Gastroenterology : WJG·Patrizia Burra, Kryssia I Rodriguez-Castro
May 5, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S Prenner, J Levitsky
Jan 1, 2017·Pediatric Transplantation·Taiichi WakiyaKenichi Hakamada
Jul 20, 2021·Journal of Clinical and Experimental Hepatology·Narendra S ChoudharyArvinder S Soin
Jul 1, 2021·Clinical Transplantation·Maneerat ChayanupatkulThomas D Schiano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
S SaigalJ O'Grady
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Nicholas OnacaGoran B Klintmalm
© 2022 Meta ULC. All rights reserved