Low relapse rate in children with acute lymphoblastic leukemia after risk-directed therapy

Journal of Pediatric Hematology/oncology
Fotini Tzortzatou-StathopoulouG T Tsangaris

Abstract

Even though acute lymphoblastic leukemia (ALL) responds well to chemotherapy, relapse remains the major problem. This study documents relapse and survival rates in 85 consecutive children (33 at good risk, 52 at high risk) with ALL diagnosed in 1991 to 1996. Until 1993, the New York II protocol for the high-risk group and a combination of UKALL XI (induction) and R blocks of ALL-REZ BFM-87 (intensification) regimens for patients at good risk were used. To reduce toxicity, the protocols were subsequently modified. Consolidation treatment was the same for both groups, consisting of a lower cytarabine dose and methotrexate removal, whereas intensification was changed only for the high-risk group using the BB block of the NHL-BFM-90 protocol. The bone marrow clearance of leukemia was assessed on day 22, and minimal residual disease was detected using polymerase chain reaction analysis of Ig heavy-chain gene rearrangements. Seventy patients had common precursor B lineage ALL, six had pre-B-ALL, eight had T-ALL, and one had B-ALL. Two patients never achieved remission and died. Six patients died of consolidation-related complications. Four more patients died, two during induction and two during maintenance therapy. Two other children...Continue Reading

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Citations

Apr 28, 2004·Journal of Pediatric Hematology/oncology·Maria MoschoviFotini Tzortzatou-Stathopoulou
May 8, 2007·Journal of Pediatric Hematology/oncology·Georgios TrimisFotini Tzortzatou-Stathopoulou
Nov 18, 2008·Journal of Pediatric Hematology/oncology·Maria MoschoviFotini Tzortzatou-Stathopoulou
Jan 7, 2010·Journal of Pediatric Hematology/oncology·Maria MoschoviIoannis Papassotiriou
Sep 30, 2005·European Journal of Haematology·Fotini Tzortzatou-StathopoulouVassiliki Syriopoulou
Dec 25, 2009·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Judith Harriet Tigay
Oct 27, 2018·Journal of Cellular Biochemistry·Nashwa El-KhazragyMenha Swellam
Mar 25, 2021·Journal of Blood Medicine·Rasha A ElkholyOla A Elshora

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