Abstract
Even though acute lymphoblastic leukemia (ALL) responds well to chemotherapy, relapse remains the major problem. This study documents relapse and survival rates in 85 consecutive children (33 at good risk, 52 at high risk) with ALL diagnosed in 1991 to 1996. Until 1993, the New York II protocol for the high-risk group and a combination of UKALL XI (induction) and R blocks of ALL-REZ BFM-87 (intensification) regimens for patients at good risk were used. To reduce toxicity, the protocols were subsequently modified. Consolidation treatment was the same for both groups, consisting of a lower cytarabine dose and methotrexate removal, whereas intensification was changed only for the high-risk group using the BB block of the NHL-BFM-90 protocol. The bone marrow clearance of leukemia was assessed on day 22, and minimal residual disease was detected using polymerase chain reaction analysis of Ig heavy-chain gene rearrangements. Seventy patients had common precursor B lineage ALL, six had pre-B-ALL, eight had T-ALL, and one had B-ALL. Two patients never achieved remission and died. Six patients died of consolidation-related complications. Four more patients died, two during induction and two during maintenance therapy. Two other children...Continue Reading
References
Apr 1, 1981·British Journal of Haematology·J M BennettC Sultan
Jan 21, 1995·Lancet·J M ChessellsS M Richards
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A SchorinS E Sallan
Apr 1, 1994·The Journal of Pediatrics·C H Pui, W M Crist
Nov 15, 1993·Cancer·P G SteinherzG Heller
Oct 28, 1993·The New England Journal of Medicine·G K RiveraW M Crist
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J VeermanA Van der Does-Van der Berg
May 1, 1996·Pediatric Hematology and Oncology·V ShantaK R Rajalekshmy
Feb 26, 1998·The New England Journal of Medicine·N Shahab, M L Evans
May 21, 1998·Leukemia·B GruhnG R Kitchingman
Aug 8, 1998·British Journal of Haematology·J M Chessells
Aug 27, 1998·The New England Journal of Medicine·H CavéE Vilmer
Aug 27, 1998·The New England Journal of Medicine·C H Pui, W E Evans
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C H PuiW E Evans
May 6, 1999·Leukemia Research·F Sackmann-MurielA M Cygler
Aug 18, 1999·Archives of Disease in Childhood·C A Stiller, E M Eatock
Sep 3, 1999·Klinische Pädiatrie·G E Janka-SchaubR Pieters
Sep 24, 1999·Medical and Pediatric Oncology·J KanervaT T Salmi
Nov 11, 1999·Leukemia·J PullenB Camitta
Mar 17, 2000·Leukemia·I HannO B Eden
May 10, 2000·Leukemia·C H Pui, D Campana
Jun 1, 2000·Archives of Disease in Childhood·J M Chessells
Citations
May 5, 2005·The Journal of Pediatrics·Daniel H BrodtmanVincent R Bonagura
Jun 24, 2003·The Journal of Laboratory and Clinical Medicine·Jagannathan RameshShaul Mordechai
Apr 28, 2004·Journal of Pediatric Hematology/oncology·Maria MoschoviFotini Tzortzatou-Stathopoulou
May 8, 2007·Journal of Pediatric Hematology/oncology·Georgios TrimisFotini Tzortzatou-Stathopoulou
Nov 18, 2008·Journal of Pediatric Hematology/oncology·Maria MoschoviFotini Tzortzatou-Stathopoulou
Jan 7, 2010·Journal of Pediatric Hematology/oncology·Maria MoschoviIoannis Papassotiriou
Apr 15, 2005·Clinical Pharmacokinetics·Vassilios I Avramis, Eduard H Panosyan
Sep 30, 2005·European Journal of Haematology·Fotini Tzortzatou-StathopoulouVassiliki Syriopoulou
Apr 24, 2016·Experimental Hematology·Michael ByrneArnon Nagler
Dec 25, 2009·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Judith Harriet Tigay
Oct 27, 2018·Journal of Cellular Biochemistry·Nashwa El-KhazragyMenha Swellam
Sep 13, 2003·Leukemia·A M MartelliL Cocco
Mar 25, 2021·Journal of Blood Medicine·Rasha A ElkholyOla A Elshora