PMID: 46026Jan 11, 1975

Low-renin hypertension: nephrosclerosis?

Lancet
J D Swales

Abstract

A substantial group of patients with essential hypertension have abnormally low renin levels which respond poorly to stimulation. Important differences in response to therapy and in prognosis have been described between these and other hypertensive patients. It is suggested that the vascular changes of nephrosclerosis, which may be seen in both hypertensive and normal subjects, result in a reduction of afferent arteriolar distensibility, with impairment of basal renin secretion and responsiveness. This hypothesis accords with both of the known clinical characteristics of low-renin hypertension and with the known effect of arterial changes upon the activity of other baroreceptors.

References

Jan 1, 1991·Cardiovascular Drugs and Therapy·P A PhillipsC I Johnston
Oct 31, 1975·The American Journal of Cardiology·J M Wallace
Jan 1, 1979·Pharmacology & Therapeutics·J D Swales
Aug 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Patricia C UnderwoodGordon H Williams
Jul 1, 1980·The American Journal of Medicine·V M CampeseV DeQuattro
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·T KokubuH Hashimoto
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·J I Robertson
Aug 1, 1989·Journal of the American Geriatrics Society·J E HallA C Guyton
May 1, 1979·Journal of the American Geriatrics Society·K ItoK Kamata
Jun 1, 1978·Kidney International·G W ThomasK M Yeates
Nov 1, 1975·Kidney International·P WeidmannJ de Lima
May 1, 1980·Hypertension·H ThurstonJ D Swales
Nov 1, 1979·The Journal of Small Animal Practice·A R Michell
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·B E Karlberg

Related Concepts

Diastolic Blood Pressure
Pressoreceptors
Essential Hypertension
Kidney
Structure of Renal Artery
Afferent Neuron
REN
Renal Hypertension
Nephrosclerosis
Preprorenin

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