PMID: 46026Jan 11, 1975

Low-renin hypertension: nephrosclerosis?

J D Swales


A substantial group of patients with essential hypertension have abnormally low renin levels which respond poorly to stimulation. Important differences in response to therapy and in prognosis have been described between these and other hypertensive patients. It is suggested that the vascular changes of nephrosclerosis, which may be seen in both hypertensive and normal subjects, result in a reduction of afferent arteriolar distensibility, with impairment of basal renin secretion and responsiveness. This hypothesis accords with both of the known clinical characteristics of low-renin hypertension and with the known effect of arterial changes upon the activity of other baroreceptors.


Jan 1, 1991·Cardiovascular Drugs and Therapy·P A PhillipsC I Johnston
Oct 31, 1975·The American Journal of Cardiology·J M Wallace
Jan 1, 1979·Pharmacology & Therapeutics·J D Swales
Aug 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Patricia C UnderwoodGordon H Williams
Jul 1, 1980·The American Journal of Medicine·V M CampeseV DeQuattro
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·T KokubuH Hashimoto
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·J I Robertson
Aug 1, 1989·Journal of the American Geriatrics Society·J E HallA C Guyton
May 1, 1979·Journal of the American Geriatrics Society·K ItoK Kamata
Jun 1, 1978·Kidney International·G W ThomasK M Yeates
Nov 1, 1975·Kidney International·P WeidmannJ de Lima
May 1, 1980·Hypertension·H ThurstonJ D Swales
Nov 1, 1979·The Journal of Small Animal Practice·A R Michell
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·B E Karlberg

Related Concepts

Diastolic Blood Pressure
Essential Hypertension
Structure of Renal Artery
Afferent Neuron
Renal Hypertension

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
J DiMartino-Nardi, M I New
Scandinavian Journal of Clinical and Laboratory Investigation
K J Kosunen
Kidney International
M J Dunn, R L Tannen
Current Hypertension Reports
M H Weinberger
© 2020 Meta ULC. All rights reserved