Low response in white blood cell DNA adducts among workers in a highly polluted cokery environment

Journal of Occupational and Environmental Medicine
T KuljukkaKimmo Peltonen

Abstract

Coke oven workers are often heavily exposed to polynuclear aromatic hydrocarbons (PAHs); this exposure has been associated with higher cancer rates among these workers. We assessed the exposure of cokery workers in an oil shale processing plant. Personal hygienic monitoring, measurement of urinary 1-hydroxypyrene (1-OHP), and analysis of PAH-DNA adducts in white blood cells (WBCs) were performed. The 32P-postlabeling method was used for adduct measurement. The mean adduct value, 1.6 adducts per 10(8) nucleotides, did not differ significantly from the control value (P = 0.098). Smokers had significantly higher adduct levels than non-smoking workers (P = 0.002). 1-OHP levels measured in post-shift samples correlated with DNA adducts found in white blood cells (WBCs). We conclude that hygienic monitoring and measurement of urinary metabolites are essential background exposure data when the biologically effective dose of chemical carcinogens is assessed.

References

Sep 1, 1978·Scandinavian Journal of Work, Environment & Health·A BjøorsethP E Fjeldstad
Dec 1, 1992·Pharmacogenetics·K VähäkangasE Yrjänheikki
Jul 1, 1992·Carcinogenesis·A C Beach, R C Gupta
Oct 1, 1991·Journal of Toxicology and Environmental Health·M V ReddyK Randerath
Oct 15, 1990·International Journal of Cancer. Journal International Du Cancer·D H PhillipsI Vincze
Jan 1, 1990·International Archives of Occupational and Environmental Health·K HemminkiA Hewer
Jan 23, 1987·Journal of Chromatography·F J JongeneelenP T Henderson
Oct 1, 1983·Environmental Health Perspectives·C K Redmond
Mar 1, 1995·Carcinogenesis·A Dipple
Feb 1, 1995·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C La VecchiaJ A Baron
Jan 1, 1993·Pharmacology & Toxicology·H E PoulsenK Wassermann
Apr 1, 1993·Journal of Toxicology and Environmental Health·J G VanRooijF J Jongeneelen
Jan 1, 1997·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·T KuljukkaK Peltonen

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Citations

Nov 4, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Valentina GalloPaolo Vineis
Jun 22, 2000·Toxicologic Pathology·A C Povey
Dec 23, 1999·Carcinogenesis·R W GodschalkF J Van Schooten
Feb 23, 2002·Journal of Exposure Analysis and Environmental Epidemiology·Terhi Kuljukka-RabbKimmo Peltonen
Nov 17, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·A G Abdel-RahmanM A Mustafa

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