Low resting diffusion capacity, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease

Journal of Applied Physiology
Amany F ElbehairyCanadian Respiratory Research Network

Abstract

The mechanisms linking reduced diffusing capacity of the lung for carbon monoxide (DlCO) to dyspnea and exercise intolerance across the chronic obstructive pulmonary disease (COPD) continuum are poorly understood. COPD progression generally involves both DlCO decline and worsening respiratory mechanics, and their relative contribution to dyspnea has not been determined. In a retrospective analysis of 300 COPD patients who completed symptom-limited incremental cardiopulmonary exercise tests, we tested the association between peak oxygen-uptake (V̇o2), DlCO, and other resting physiological measures. Then, we stratified the sample into tertiles of forced expiratory volume in 1 s (FEV1) and inspiratory capacity (IC) and compared dyspnea ratings, pulmonary gas exchange, and respiratory mechanics during exercise in groups with normal and low DlCO [i.e., <lower limit of normal (LLN)] using Global Lung Function Initiative reference values. DlCO was associated with peak V̇o2 (P = 0.006), peak work-rate (P = 0.005), and dyspnea/V̇o2 slope (P < 0.001) after adjustment for other independent variables (airway obstruction and hyperinflation). Within FEV1 and IC tertiles, peak V̇o2 and work rate were lower (P < 0.05) in low versus normal DlCO...Continue Reading

References

Feb 1, 1977·The Journal of Clinical Investigation·P D WagnerJ B West
Jan 1, 1990·The American Review of Respiratory Disease·N J MorrisonK G Evans
Apr 1, 1987·Journal of Applied Physiology·P D WagnerL Lagerstrand
Jul 1, 1986·Journal of Applied Physiology·P D WagnerH A Saltzman
Jan 1, 1985·Clinical Physiology·P D Wagner
Dec 1, 1971·Journal of Applied Physiology·P D WagnerJ B West
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Jan 1, 1995·International Journal of Behavioral Medicine·E G EakinR M Kaplan
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Dror OfirDenis E O'Donnell
Jun 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel NeebLaura Maria Schreiber
Nov 16, 2010·Respiratory Medicine·Thomas B GrydelandPer S Bakke
Sep 3, 2011·American Journal of Respiratory and Critical Care Medicine·Pierantonio LavenezianaDenis E O'Donnell
Jun 14, 2014·The European Respiratory Journal·Jerome A Dempsey, Curtis A Smith
Aug 28, 2014·Expert Review of Respiratory Medicine·Daniel LangerDenis E O'Donnell
Oct 8, 2014·Annals of the American Thoracic Society·Richard CasaburiUNKNOWN 205.440 Investigators
Nov 2, 2014·The European Respiratory Journal·J Alberto NederDenis E O'Donnell
Apr 1, 2015·American Journal of Respiratory and Critical Care Medicine·Amany F ElbehairyUNKNOWN Canadian Respiratory Research Network
Jun 13, 2015·American Journal of Respiratory and Critical Care Medicine·Katja HueperR Graham Barr
Sep 26, 2015·American Journal of Respiratory and Critical Care Medicine·Azmy FaisalDenis E O'Donnell
Sep 2, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Denis E O'DonnellDonald A Mahler
Apr 4, 2017·COPD·Amany F ElbehairyUNKNOWN Canadian Respiratory Research Network (CRRN)
Apr 12, 2017·Annals of the American Thoracic Society·Denis E O'DonnellUNKNOWN Canadian Respiratory Research Network
Apr 21, 2017·The European Respiratory Journal·Denis E O'DonnellFrançois Maltais
Jul 1, 2017·American Journal of Respiratory and Critical Care Medicine·Alcides RochaJ Alberto Neder
Aug 27, 2017·BMC Pulmonary Medicine·Mehrdad BehniaBruce Johnson
Sep 13, 2017·The European Respiratory Journal·Sanja StanojevicUNKNOWN Global Lung Function Initiative (GLI) TLCO
Nov 11, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Mehrdad BehniaBruce D Johnson
Feb 16, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Diana CrossleyAlice M Turner
Mar 27, 2018·Respiratory Physiology & Neurobiology·Amany F ElbehairyUNKNOWN Canadian Respiratory Research Network (CRRN)
Oct 24, 2018·International Journal of Chronic Obstructive Pulmonary Disease·Luiz Carlos S Carvalho-JrAudrey Borghi-Silva

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Citations

Apr 29, 2020·American Journal of Respiratory and Critical Care Medicine·J Alberto NederUNKNOWN Canadian Respiratory Research Network (CRRN) and the Canadian Cohort of Obstructive Lung Disease (CanCOLD) Collaborative Res
Sep 10, 2020·Frontiers in Medicine·Matthew D JamesDenis E O'Donnell
Jul 28, 2020·Frontiers in Physiology·Devin B PhillipsMichael K Stickland
Oct 29, 2020·Clinical Physiology and Functional Imaging·Paulo T Muller, Erlandson F Saraiva
Nov 9, 2020·Respiratory Physiology & Neurobiology·Devin B PhillipsUNKNOWN Canada Respiratory Research Network (CRRN)
Apr 9, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Devin B PhillipsUNKNOWN Canadian Respiratory Research Network (CRRN)
Jun 30, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bruce R Thompson
Jul 22, 2021·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Renata D MarquesJosé Alberto Neder
Sep 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·J Alberto NederDenis E O'Donnell
Oct 15, 2021·Medicine and Science in Sports and Exercise·Devin B PhillipsUNKNOWN Canadian Respiratory Research Network

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