Low-risk donor lungs optimize the post-lung transplant outcome for high lung allocation score patients

Surgery Today
Takeshi KurosakiTakahiro Oto

Abstract

The lung allocation score (LAS) has been generally recognized as a contributor to the overall survival in lung transplant candidates. However, donor-related risks have never been taken into consideration in previous research that validated the LAS. This study aimed to determine whether or not the role of the LAS as a predictor of the posttransplant outcome is influenced by the quality of the donor lungs. We retrospectively reviewed 108 patients who underwent lung transplantation at Okayama University Hospital since 1998. The cohort was divided into two groups based on the lung donor score (DS; ≤ 4/> 4). Correlations between the LAS and posttransplant outcomes were investigated in both groups. In the high-DS group, an elevated LAS was strongly associated with posttransplant PaO2/FiO2 (p = 0.018). However, in the low-DS group, no correlation was found between them. There was no significant difference in the long-term survival according to the LAS in the low-DS group. The LAS effectively predicted the posttransplant outcome only when lungs with DS > 4 were transplanted; the LAS was not reliable if high-quality lungs were transplanted. Lung transplantation can be feasible and provides a survival benefit even for high-LAS patients i...Continue Reading

References

Apr 8, 1999·The New England Journal of Medicine·S M Arcasoy, R M Kotloff
Apr 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T M EganF L Grover
Dec 23, 2006·The Annals of Thoracic Surgery·Takahiro OtoGregory I Snell
Jan 9, 2008·The Journal of Thoracic and Cardiovascular Surgery·Benjamin D KozowerDavid R Jones
Feb 4, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V LiuD Weill
Dec 16, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Jacqueline M SmitsBruno Meiser
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Robert M Kotloff, Gabriel Thabut
Apr 15, 2011·The New England Journal of Medicine·Marcelo CypelShaf Keshavjee
Dec 24, 2011·The Annals of Thoracic Surgery·Tetsuya HoraiYoshiya Toyoda
Jan 22, 2013·The Journal of Thoracic and Cardiovascular Surgery·Yoshiya ToyodaChristian Bermudez
Aug 21, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Wiebke SommerGregor Warnecke
Oct 29, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Paula MorenoAngel Salvatierra
May 21, 2014·General Thoracic and Cardiovascular Surgery·Masaaki SatoUNKNOWN Japanese Society of Lung and Heart–Lung Transplantation
Oct 1, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Jana SomersDirk E Van Raemdonck
Jan 13, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A K IsraniB L Kasiske
Jan 16, 2016·Interactive Cardiovascular and Thoracic Surgery·Jeremiah W Awori HayangaJonathan D'Cunha
Feb 4, 2016·American Journal of Respiratory and Critical Care Medicine·Don HayesDmitry Tumin

❮ Previous
Next ❯

Citations

May 9, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Justin N TawilMichael L Boisen
Oct 14, 2020·International Journal of Surgery Case Reports·Valeria MussoAlessandro Palleschi
Jun 14, 2021·Transplantation Proceedings·Takeshi KurosakiShinichi Toyooka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.