Abstract
To assess whether the hepatitis B virus (HBV), the hepatitis C virus (HCV), and the human immunodeficiency virus (HIV) are transmitted to hemophiliacs by a high-purity factor VIII concentrate in which the method of virus inactivation is pasteurization. Hepatitis B virus markers, the antibody to HCV (anti-HCV), the antibody to HIV (anti-HIV), and aminotransferases were measured on serum samples collected before the first concentrate infusion and at regular time intervals thereafter. Seventeen hemophilia centers in Italy, the Federal Republic of Germany, Belgium, Austria, and the Democratic Republic of Germany. Twenty-nine patients with hemophilia A who had not received a previous transfusion with blood products and who had normal alanine and aspartate aminotransferases (ALT and AST) were included in the final analysis. No patient became positive for anti-HCV or anti-HIV or developed sustained increases in aminotransferase levels. Similarly, none of the 15 unvaccinated patients developed markers of HBV infection. This prospective study conducted in previously untransfused hemophiliacs highly susceptible to developing post-transfusion hepatitis shows that a large-pool clotting factor concentrate treated with pasteurization carries...Continue Reading
Citations
Feb 1, 1992·Journal of Medical Virology·T Di PaolantonioM Schiavoni
Jan 1, 1994·Annals of Hematology·E Berntorp
May 23, 1992·Lancet·N Ciavarella, M Schiavoni
Jan 6, 2000·Journal of Hepatology·C L van der Poel
Jun 1, 1996·Baillière's Clinical Haematology·P M Mannucci
Jun 1, 1992·Biologicals : Journal of the International Association of Biological Standardization·T Burnouf
Mar 13, 2012·Journal of the American Chemical Society·Izumi SakamotoYasuhiro Kajihara
Jan 1, 1993·Vox Sanguinis·S ArrighiM G Borri
Jan 1, 1993·Vox Sanguinis·P M Mannucci
Apr 29, 2005·International Journal of Clinical Practice·H J Longhurst
Dec 18, 2012·Cardiovascular Psychiatry and Neurology·Jack C de la Torre
May 12, 2012·Stroke Research and Treatment·Irena Martinić-PopovićVida Demarin
Apr 16, 2013·BioMed Research International·Michael Mu Huo TengFeng-Chi Chang
Dec 24, 2013·Thrombosis Research·Stefan Schulte
Sep 26, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Solveig TenckhoffHans L Tillmann
Apr 1, 1992·Transfusion Medicine Reviews·K J Smith
Apr 1, 1991·Baillière's Clinical Haematology·D J King
Jan 13, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·E SantagostinoA Bianchi Bonomi
Jan 1, 1990·Viral Immunology·D R LuceyR N Boswell
Oct 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·E BerntorpA Widell
Jan 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·P M Mannucci
Mar 1, 1996·Journal of Viral Hepatitis·Y FujimuraM Mayumi
Sep 1, 1991·Annals of Hematology·J M Lusher
Mar 23, 2002·Paediatric Drugs·Elena SantagostinoPier M Mannucci
Jan 1, 1991·Vox Sanguinis·J A Barbara, M Contreras
Mar 1, 1992·American Journal of Hematology·A AzziP M Mannucci
Apr 9, 2002·Clinical Orthopaedics and Related Research·Hisashi IwataThomas W Bauer