Low risk of HBV reactivation in a large European cohort of HCV/HBV coinfected patients treated with DAA.

Expert Review of Anti-infective Therapy
Jerzy JaroszewiczRobert Flisiak

Abstract

The aim of the study was to analyze the prevalence and clinical characteristics of HCV/HBV coinfection and to evaluate the rate of HBV-reactivation during anti-HCV therapy in a large real-world study. Analyzed population consisted of 10,152 chronic hepatitis C patients treated with DAA between 2015 and 2019 in a nationwide study. Prior to the DAA all subjects had HBsAg and 60% anti-HBc testing. 111 of 10,152 patients (1.1%) had detectable HBsAg and 1239 of 6139 (20.2%) anti-HBcAb. The prevalence of occult hepatitis B was 0.48%. HCV/HBV patients were younger with a higher proportion of males, HIV-coinfected, and advanced fibrosis. They were less often diagnosed with diabetes but more often with chronic kidney disease. In HBsAg(+) subjects with baseline HBV-DNA available 6/102 (5.9%) HBV-reactivations during or after DAA therapy were observed, and in two (1.9%) significant hepatic flares were noted. In HBsAg(-)/anti-HBc(+) group 2 (0.16%) reactivations were observed only in patients undergoing immunosuppressive therapy. Data from a large European cohort suggest a relatively low risk of HBV-reactivation during DAA-therapy for HCV infection in HBsAg(+) patients. In HBsAg(-)/anti-HBc(+) HBV-reactivation seems to be limited to subjec...Continue Reading

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Citations

Jun 25, 2020·Expert Review of Anti-infective Therapy·Dorota Zarębska-MichalukMarta Flisiak-Jackiewicz
Jul 8, 2021·The Pediatric Infectious Disease Journal·Maria Pokorska-ŚpiewakMagdalena Marczyńska
Dec 24, 2021·Expert Opinion on Pharmacotherapy·Rachael Jacob, Mark Danta

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