PMID: 11919242Mar 29, 2002Paper

Low-risk persistent gestational trophoblastic disease: outcome after initial treatment with low-dose methotrexate and folinic acid from 1992 to 2000

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
I A McNeishE S Newlands

Abstract

We have simplified the treatment of gestational trophoblastic disease (GTD) in order to reduce the number of patients exposed to potentially carcinogenic chemotherapy. Patients who score 0 to 8 on the Charing Cross scoring system are classified as low-risk and receive methotrexate (MTX) and folinic acid (FA), whereas those who score higher than 8 are classified as high-risk and receive the etoposide, methotrexate, and dactinomycin (EMA)/cyclophosphamide and vincristine (CO) regimen. Between 1992 and 2000, 485 women with GTD were commenced on MTX/FA at Charing Cross Hospital, London, United Kingdom. If patients developed MTX resistance or toxicity, treatment was altered according to the level of beta human chorionic gonadotropin (hCG). If serum hCG was < or = 100 IU/L, patients received dactinomycin; if hCG was greater than 100 IU/L, patients received EMA/CO. The median duration of follow-up was 4.7 years. Overall survival was 100% and the relapse rate was 3.3% (16 of 485 patients). hCG values normalized in 324 (66.8%) of 485 patients with MTX alone, whereas 161 (33.2%) of 485 patients required a change in treatment, 11 because of MTX toxicity and 150 because of MTX resistance. Sixty-seven patients changed to dactinomycin, of wh...Continue Reading

References

Jul 1, 1989·British Journal of Obstetrics and Gynaecology·K D BagshaweG J Rustin
Jan 1, 1986·British Journal of Obstetrics and Gynaecology·E S NewlandsJ Dent
Jul 1, 1994·Gynecologic Oncology·J T SoperC B Hammond
Feb 1, 1993·British Journal of Obstetrics and Gynaecology·D B SmithK D Bagshawe
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G J RustinD Short
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M BowerK D Bagshawe
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BowerK D Bagshawe
Mar 31, 1999·British Journal of Cancer·A M GillespieB W Hancock
Dec 20, 2000·American Journal of Obstetrics and Gynecology·L C WongT Y Ng
Mar 10, 2001·Obstetrics and Gynecology·K SuzukaS Sekiya
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B.W. HancockE.S. Newlands

❮ Previous
Next ❯

Citations

Jan 15, 2013·European Journal of Nuclear Medicine and Molecular Imaging·P MapelliM Candiani
Mar 6, 2009·Archives of Gynecology and Obstetrics·Mitra MohitAmir Vasheghani-Farahani
Oct 16, 2004·Current Oncology Reports·Naveed SarwarMichael J Seckl
Sep 21, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·S GuliaS Menon
Nov 15, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·E S Newlands
Nov 5, 2008·Nature Clinical Practice. Oncology·Philip SavageTim Crook
May 6, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J WangM J Seckl
Sep 4, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J SecklUNKNOWN ESMO Guidelines Working Group
Sep 16, 2003·Clinical Obstetrics and Gynecology·Michael E Carney
Sep 1, 2007·Current Opinion in Oncology·Sarah Ngan, Michael J Seckl
Jan 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raymond J OsborneJanice M Lage
Dec 15, 2010·Future Oncology·Constantine Alifrangis, Michael J Seckl
Feb 18, 2014·Current Obstetrics and Gynecology Reports·Siew-Fei Ngu, Karen K L Chan
Oct 17, 2014·Current Oncology Reports·Fieke E M Froeling, Michael J Seckl
Feb 24, 2012·Journal of Cancer Research and Clinical Oncology·Adnan AydinerErkan Topuz
Aug 4, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eyad Al-SalehMoorkath Nandakumaran
Jan 9, 2010·Fetal and Pediatric Pathology·N J Sebire, Iain Lindsay
May 10, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P M SavageM J Seckl
Feb 2, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S WhiteP Savage
Aug 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Angiolo GadducciStefania Cosio
Nov 13, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·E Al-SalehW Al-Jassar
Oct 31, 2015·Expert Review of Anticancer Therapy·Donald P GoldsteinNeil S Horowitz
Apr 7, 2016·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Ansar HussainA R Lone
Aug 11, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Angela M Baptista, Paulo Belfort
Dec 9, 2008·Gynecologic Oncology·Whitfield B GrowdonRoss S Berkowitz
Jul 18, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Fariba YarandiParviz Hanjani
Oct 5, 2007·The Lancet Oncology·N E van TrommelC M G Thomas
Oct 19, 2007·Gynecologic Oncology·Rosemary A FisherMichael J Seckl
Jan 13, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Soo-Keat Khoo
Mar 11, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Zabeena PandianD A Russell Lees
Jan 21, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P CavorettoM Candiani
Aug 29, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·C LybolL F A G Massuger
Dec 17, 2009·The Mount Sinai Journal of Medicine, New York·Jamal RahamanHerbert Gretz Iii
Oct 13, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·M VreeC Lok
Jun 28, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nisrin AnfinanHesham Sait
Mar 21, 2006·Clinical Radiology·S D AllenA W Mitchell
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hextan Y S NganJohn R Lurain
Nov 9, 2016·Journal of Obstetrics and Gynaecology of India·Ansar HussainNadeem Qazi
Apr 28, 2009·American Journal of Obstetrics and Gynecology·Gihad Elias ChalouhiDaniel Raudrant

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.