Low-risk Prostate Cancer Prior to or After Kidney Transplantation

European Urology Focus
Michael StöcklePaolo Fornara

Abstract

Organ transplantation requires immunosuppression, which was regarded as a risk factor for tumor induction and tumor progression in all types of malignancy. Until recently, any form of active neoplasia was, therefore, regarded as contraindicative to organ transplantation. However, there is growing evidence that the increased tumor risk by immunosuppression is restricted to particular subgroups of malignancy, whereas others such as prostate cancer (PCa) are not negatively influenced. To compare life expectancy (LE) under various low-risk situations of PCa (untreated low-risk primary tumor, slowly progressing asymptomatic biochemical recurrence after curative treatment) with LE under renal replacement therapy. To discuss the question whether or not low-risk untreated or incurable situations of PCa must be regarded contraindicative to kidney transplantation (KT) or to transplantation of other organs. A systematic literature search was conducted using PubMed to identify original and review articles regarding PCa risk after KT as well as the natural history of untreated and treated situations of PCa. Articles published between 1991 and 2018 were reviewed and selected with the consensus of all the authors. No evidence could be found t...Continue Reading

Citations

May 10, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Uwe BieriMarian S Wettstein
Sep 25, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·David P Al-AdraKymberly D Watt
Jan 12, 2021·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·T CultyM-O Timsit
Aug 28, 2021·Journal of Clinical Medicine·Boyeon KimKyung-A Lee

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