Low SAFB levels are associated with worse outcome in breast cancer patients

Breast Cancer Research and Treatment
Stephanie Hammerich-HilleSteffi Oesterreich

Abstract

The scaffold attachment factors SAFB1 and SAFB2 have been shown to function as estrogen receptor (ERalpha) co-repressors in breast cancer cells, and to affect many cellular processes such as stress response, RNA processing, and apoptosis. SAFB1 and SAFB2 have also been implicated in breast tumorigenesis: Their shared chromosomal locus at 19p13 is frequently lost in breast cancer, mutations have been identified, and overexpression results in growth inhibition. The purpose of this study was to determine SAFB1/SAFB2 protein expression in human breast tumors, to correlate their expression with either natural progression ("prognostic factor") or with response to Tamoxifen ("predictive factor"), and to analyze potential correlations with tumor characteristics. SAFB1/SAFB2 protein were measured by immunoblotting using a pan-SAFB antibody in tumor extracts from patients with long-term clinical follow-up (n = 289), a subset of whom had received no adjuvant systemic therapy after breast cancer surgery (n = 117) and another subset of whom were treated with adjuvant Tamoxifen (n = 172). SAFB levels were correlated with clinico-pathological variables and patient outcome. SAFB levels varied widely, with 25 tumors not expressing detectable le...Continue Reading

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Citations

Sep 20, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lucia E RosasDouglas M McCarty
Mar 10, 2009·Molecular Cancer·Benny Abraham KaipparettuSteffi Oesterreich
Sep 6, 2012·Endocrine Reviews·Bramanandam ManavathiRakesh Kumar
Apr 28, 2010·PloS One·Catalina Alfonso-Parra, Keith A Maggert
May 9, 2012·Journal of Cellular Biochemistry·Takashi HashimotoMitsuhiro Kawata
Nov 11, 2009·The Journal of Biological Chemistry·Stephanie Hammerich-HilleSteffi Oesterreich
Oct 18, 2018·Bioinformatics·Hao DingRaghu Machiraju
Jul 24, 2012·Biochemical Society Transactions·Elaine A HongAlison J Tyson-Capper
Jun 15, 2020·Clinical and Translational Medicine·Olga KelemenGyorgy Marko-Varga
Feb 23, 2020·Histochemistry and Cell Biology·Takashi HashimotoKen-Ichi Matsuda
Oct 21, 2015·Journal of Translational Medicine·Clizia ChinelloFulvio Magni
Sep 16, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hong-Li JiaoYan-Qing Ding
Mar 7, 2021·Basic Research in Cardiology·Shenjian LuoZhenwei Pan
Jul 18, 2014·Cellular and Molecular Life Sciences : CMLS·Zhuan ZhouYong Wan

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