Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice

Hypertension
Paramita PatiR Daniel Rudic

Abstract

Blood pressure exhibits a robust circadian rhythm in health. In hypertension, sleep apnea, and even shift work, this balanced rhythm is perturbed via elevations in night-time blood pressure, inflicting silent damage to the vasculature and body organs. Herein, we examined the influence of circadian dysfunction during experimental hypertension in mice. Using radiotelemetry to measure ambulatory blood pressure and activity, the effects of angiotensin II administration were studied in wild-type (WT) and period isoform knockout (KO) mice (Per2-KO, Per2, 3-KO, and Per1, 2, 3-KO/Per triple KO [TKO] mice). On a normal diet, administration of angiotensin II caused nondipping blood pressure and exacerbated vascular hypertrophy in the Period isoform KO mice relative to WT mice. To study the endogenous effects of angiotensin II stimulation, we then administered a low-salt diet to the mice, which does stimulate endogenous angiotensin II in addition to lowering blood pressure. A low-salt diet decreased blood pressure in wild-type mice. In contrast, Period isoform KO mice lost their circadian rhythm in blood pressure on a low-salt diet, because of an increase in resting blood pressure, which was restorable to rhythmicity by the angiotensin re...Continue Reading

References

Apr 15, 1978·Lancet·M W Millar-CraigE B Raftery
Aug 13, 1988·Lancet·E O'BrienK O'Malley
Nov 1, 1986·The Journal of Clinical Investigation·J R IngelfingerV J Dzau
May 20, 1998·The Journal of Clinical Endocrinology and Metabolism·J R PetrieJ McConnell
Jan 4, 2001·The New England Journal of Medicine·F M SacksUNKNOWN DASH-Sodium Collaborative Research Group
May 25, 2005·Atherosclerosis·Ognen IvanovskiMartin Muntzel
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anne M CurtisGarret A Fitzgerald
Apr 4, 2007·Circulation·Hema ViswambharanZhihong Yang
May 10, 2008·Journal of General Internal Medicine·Hillel W CohenMichael H Alderman
Jan 28, 2009·Hypertension·Alejandro de la SierraUNKNOWN Spanish Society of Hypertension Ambulatory Blood Pressure Monitoring Registry Investigators
Mar 11, 2009·Circulation·Ciprian B AneaR Daniel Rudic
Jul 10, 2009·The Journal of Clinical Investigation·Michelle L GumzCharles S Wingo
Aug 15, 2009·Journal of Applied Physiology·R Daniel Rudic, David J Fulton
Oct 29, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hitoshi AndoAkio Fujimura
Jan 8, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana VukolicJean-Pierre Montani
Feb 4, 2010·JAMA : the Journal of the American Medical Association·Michael H Alderman
Sep 11, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Ciprian B AneaR Daniel Rudic
Sep 22, 2010·Chronobiology International·Ramón C HermidaJosé R Fernández
Nov 3, 2010·Metabolism: Clinical and Experimental·Rajesh GargGail K Adler
Jan 29, 2011·Journal of the American Society of Hypertension : JASH·Anthony J VieraDavid R Jacobs
Feb 11, 2011·Diabetes Care·Merlin C ThomasUNKNOWN FinnDiane Study Group
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Bo ChengR Daniel Rudic
Nov 24, 2011·JAMA : the Journal of the American Medical Association·Martin J O'DonnellRoland E Schmieder
Jun 19, 2012·The Journal of Nutritional Biochemistry·Hong LuAlan Daugherty
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 2, 2013·Sleep·Daniel S EvansUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Group
May 25, 2013·Science·Kai Kupferschmidt
Jun 7, 2013·Chronobiology International·Katrin AckermannManfred Kayser
Jan 10, 2014·Scandinavian Journal of Work, Environment & Health·Massimo BracciLory Santarelli
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Simon N ArcherDerk-Jan Dijk
Aug 15, 2014·The New England Journal of Medicine·Martin O'DonnellUNKNOWN PURE Investigators
Aug 15, 2014·The New England Journal of Medicine·Suzanne Oparil

❮ Previous
Next ❯

Citations

Jan 20, 2016·Hypertension·Jing Wu, Curt D Sigmund
Oct 3, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Airi Otsuka, Tetsuya Shiuchi
Oct 23, 2019·Annual Review of Physiology·Dingguo Zhang, David M Pollock
Mar 20, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Lin ChangY Eugene Chen
Jun 6, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Siân P CartlandMary M Kavurma
Jul 31, 2016·Experimental Physiology·Michelle L Gumz
May 16, 2017·Current Hypertension Reports·Branko BraamShereen M Hamza
Sep 19, 2020·Journal of Physiology and Biochemistry·Haoran HuangHui Huang
Dec 17, 2020·Physiology·Jessica R Ivy, Matthew A Bailey
Jan 17, 2021·Experimental Gerontology·Zhuoying ChenXiangjie Liu
Jun 25, 2021·American Journal of Hypertension·Reham H Soliman, David M Pollock
Sep 14, 2021·Kidney & Blood Pressure Research·Zhengmei FangYingshui Yao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.