Low serum 25-hydroxyvitamin D concentrations are associated with increased likelihood of having depressive symptoms among Japanese workers

The Journal of Nutrition
Tetsuya MizoueA Nanri

Abstract

Accumulating evidence suggests a protective role of vitamin D against mood disorders; however, epidemiologic studies are scarce in working populations. We investigated cross-sectionally the association of serum vitamin D status and depressive symptoms among Japanese workers. Participants were 1786 employees (9% women), aged 19-69 y, who received health check-ups and participated in a nutrition and health survey. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured with the use of a competitive protein binding assay. Depressive symptoms were assessed by using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression was used to estimate ORs with adjustment for potential confounding variables including dietary factors. Overall, 92% of study participants had suboptimal vitamin D status [25(OH)D <30 μg/L]. Depressive symptoms were inversely associated with 25(OH)D. Compared with those with a 25(OH)D concentration of <20 μg/L, multivariable-adjusted ORs (95% CIs) for depressive symptoms (CES-D scale score ≥16) were 0.75 (0.59, 0.95) and 0.66 (0.41, 1.06) for those with a 25(OH)D concentration of 20-29 μg/L and ≥30 μg/L, respectively (P-trend = 0.01). After further adjustment for leisure-time phys...Continue Reading

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Citations

Oct 25, 2016·Journal of Psychosomatic Research·Young-Chul ShinSe-Won Lim
Oct 13, 2019·Journal of Diabetes Investigation·Nobuaki SakamotoSeitaro Dohi
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