Low Serum 25-Hydroxyvitamin D Levels Are Associated with Dry Eye Syndrome

PloS One
Sam Young YoonWon Ryang Wee

Abstract

Dry eye syndrome (DES) is a common tear film and ocular surface disease that results in discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. Systemic diseases associated with DES include diabetes mellitus, rheumatoid arthritis, depression, anxiety, thyroid disease, allergic diseases, irritable bowel syndrome, chronic pain syndrome, and hyperlipidemia. Interestingly, it has been found that most of these are associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) or inadequate sunlight exposure. In this cross-sectional data analysis, noninstitutionalized adults aged ≥19 years (N = 17,542) who participated in Korean National Health and Nutrition Examination Survey 2010-2012 were included. Information regarding duration of sunlight exposure was collected from the survey participants. Serum 25(OH)D and zinc levels were measured. The confounding variables were age, gender, sunlight exposure time, region of residence, obesity, serum 25(OH)D level, diabetes mellitus, rheumatoid arthritis, depression, thyroid disorder, atopic dermatitis, history of ocular surgery, regular exercise, and walking exercise. Mean serum 25(OH)D levels of subjects with and without DES were 16.90 ± 6.0...Continue Reading

References

Apr 1, 1988·The Journal of Physiology·C PeterfyE Yu
Jun 6, 1998·Eye·N A BrownH M Dewar
May 4, 2000·Acta Ophthalmologica Scandinavica·L A WickhamD A Sullivan
Sep 1, 2000·The American Journal of Clinical Nutrition·J WortsmanM F Holick
Jan 29, 2002·American Journal of Ophthalmology·Eiki GotoKazuo Tsubota
Nov 26, 2002·The British Journal of Ophthalmology·A J LeeD T H Tan
Mar 5, 2003·Advances in Experimental Medicine and Biology·Sawako H Hibino, Hitoshi Watanabe
Aug 5, 2003·The American Journal of Emergency Medicine·Zahide DoganayHakan Guven
Nov 6, 2004·International Journal of Circumpolar Health·Jóhann AxelssonRagnar Sigbjörnsson
Nov 18, 2005·American Journal of Ophthalmology·Miho FujitaHiroshi Takahashi
Aug 11, 2006·The Ocular Surface·Patricia BuchholzFrancisco C Figueiredo
Jan 30, 2007·Diabetes Care·Gregory A NicholsJonathan B Brown
Feb 24, 2007·American Journal of Ophthalmology·Biljana MiljanovićDebra A Schaumberg
Apr 12, 2007·The Journal of Clinical Endocrinology and Metabolism·N BinkleyM K Drezner
May 15, 2007·Environment International·Peder Wolkoff, Søren K Kjaergaard
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Nov 9, 2007·The New England Journal of Medicine·Roger BouillonPaul Lips
Dec 8, 2007·European Journal of Drug Metabolism and Pharmacokinetics·Walter E Stumpf, Naohiko Hayakawa
Mar 14, 2008·Endocrine·Miriam BlumBess Dawson-Hughes
Jul 29, 2008·The British Journal of Ophthalmology·N LoisJ G Ayres
Aug 19, 2008·Ophthalmology·Miki UchinoKazuo Tsubota
Nov 26, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Christina KrämerJörg Reichrath
Apr 21, 2010·Archives of Dermatology·Catherine E Mosher, Sharon Danoff-Burg
Aug 13, 2010·Journal of Strength and Conditioning Research·C Martyn BeavenWill G Hopkins
May 11, 2011·Archives of Ophthalmology·Sang Beom HanKi Woong Kim
Jul 1, 2011·Investigative Ophthalmology & Visual Science·Zhaohong YinMitchell A Watsky
Oct 26, 2011·The Ocular Surface·John WongLouis Tong
Jan 11, 2012·Archives of Ophthalmology·William StevensonReza Dana
Jan 18, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·S Y RheeJ-T Woo
Mar 20, 2012·Progress in Retinal and Eye Research·Stefano BarabinoReza Dana
Apr 6, 2012·PloS One·Motoko KawashimaKazuo Tsubota
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Beda Muehleisen, Richard L Gallo
Jan 21, 2014·The Ocular Surface·Cecilia ChaoFiona Stapleton
Jan 29, 2014·International Journal of Rheumatic Diseases·Sükran ErtenCemile Koca
Mar 1, 2014·Investigative Ophthalmology & Visual Science·Jawaher A AlsalemGraham R Wallace
Apr 3, 2014·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Susan TruongBlanka Golebiowski
Apr 12, 2014·Investigative Ophthalmology & Visual Science·Xiaowen Lu, Mitchell A Watsky

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Citations

Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Nasim JamaliNader Sheibani
Dec 7, 2017·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Da-Hye JeonHyeon Chang Kim
Jan 23, 2019·Journal of Clinical Laboratory Analysis·Yu Tsun LaiFernando Luiz Affonso Fonseca
Mar 30, 2019·Investigative Ophthalmology & Visual Science·Bum-Joo ChoJoon Young Hyon
Mar 10, 2019·The British Journal of Dermatology·B AkinladeA Wollenberg
Jun 14, 2019·Investigative Ophthalmology & Visual Science·Pooja KhamarSwaminathan Sethu
Apr 18, 2020·Investigative Ophthalmology & Visual Science·Jin Sun HwangYoung Joo Shin
Sep 7, 2016·Eye and Vision·Swaminathan SethuArkasubhra Ghosh
May 17, 2017·Journal of the American Veterinary Medical Association·Valerie J ParkerDennis J Chew
Apr 3, 2020·Nutrients·Marco PellegriniGiuseppe Giannaccare
May 11, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yi-Fang MengPan Xiao
May 29, 2020·Indian Journal of Ophthalmology·Uma Sridhar, Koushik Tripathy
Mar 25, 2020·International Ophthalmology·Seyhan DikciTülay Yıldırım

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