PMID: 6403137Mar 19, 1983Paper

Low serum C4 concentrations: an inherited predisposition to insulin dependent diabetes?

British Medical Journal
D VerganiA H Barnett

Abstract

Twenty two out of 86 insulin dependent diabetics had serum C4 concentrations below the normal range. None of 41 non-insulin dependent diabetics tested had low concentrations. Low C4 values were seen in insulin dependent diabetes irrespective of the duration of the disease and did not appear to correlate with complement activation. There was a close correlation in C4 values between identical cotwins, even when only one was diabetic. These results suggest that a low serum C4 concentration is an inherited phenomenon and may predispose towards the development of insulin dependent diabetes.

References

Dec 11, 1976·Lancet·R LendrumD R Gamble
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G J O'NeillB Dupont
Jul 1, 1971·The Journal of Experimental Medicine·L EllmanM M Frank
Jan 2, 1982·Lancet·J BertramsS Schoeps
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Z L Awdeh, C A Alper
Dec 25, 1980·The New England Journal of Medicine·M J DobersenA L Notkins
Jan 1, 1981·Human Genetics·C Rittner, J Bertrams
Feb 1, 1981·Diabetologia·A H BarnettD A Pyke

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Citations

Jun 1, 1987·Diabetologia·J A CharlesworthN Howard
Apr 1, 1989·European Journal of Pediatrics·F ChiarelliG Morgese
Aug 2, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G C K W KohW J Wiersinga
Oct 12, 1985·Lancet·F T ChristiansenR L Dawkins
Jul 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·D F ChildC J Smith
Oct 13, 1984·British Medical Journal·A H BarnettA R Bradwell
Mar 22, 1986·British Medical Journal·M E CooperG Jerums
Feb 1, 1988·European Journal of Pediatrics·F ChiarelliG Morgese
Sep 15, 2015·The Journal of Pathology·Katherine N Gibson-CorleyJohn F Engelhardt
Aug 5, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·A H Barnett
May 1, 1984·Clinical and Experimental Dermatology·N R Rowell
May 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·S G GilbeyP J Watkins
Nov 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·A N Gorsuch
Jul 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jakob ØstergaardAllan Flyvbjerg
Nov 27, 1999·FEMS Immunology and Medical Microbiology·S E Geerlings, A I Hoepelman
May 1, 1985·Clinical Immunology and Immunopathology·J S SundsmoM A Charles
Oct 14, 1988·Diabetes Research and Clinical Practice·Y MorimotoY Arimoto
Mar 22, 1986·British Medical Journal·A J White, B Barraclough
Oct 19, 2017·Nature Reviews. Nephrology·Mia J SmithJohn C Cambier
Jul 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·D Vergani
Jun 13, 2009·Journal of Immunotoxicology·A K DaoudN Abu Harfeil
Jul 28, 2012·Human Mutation·Stuart Cantsilieris, Stefan J White

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