Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of Alzheimer's disease

Psychoneuroendocrinology
Patrick QuinlanJohan Svensson

Abstract

In epidemiological studies, thyroid hormones (THs) have been associated with the risk of dementia. However, little is known of the relation between THs and risk of Alzheimer's disease (AD) or vascular dementia (VaD) in a memory clinic population. In a mono-center study, serum concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were assessed in 302 patients. All patients had subjective or objective mild cognitive impairment and none received treatment with THs. Cox proportional hazards regression analyses was used to determine whether THs at baseline were associated with the risk of conversion to all-cause dementia, AD or VaD. During the follow-up (mean 2.8 years), 82 (28%) of the patients progressed to dementia [AD, n = 55 (18%) and VaD, n = 17 (6%)]. Serum concentrations of TSH, FT4, and FT3 did not associate with all-cause dementia or VaD. Higher serum FT3 was associated with lower risk of conversion to AD [hazard ratio (HR) = 054; 95% confidence interval (CI): 0.32-0.92 per 1 pmol/L increase]. Furthermore, patients in the lowest serum FT3 quartile had a twofold increased risk of AD compared to those in the highest quartile (HR = 2.63; 95% CI: 1.06-6.47). These associatio...Continue Reading

Citations

Nov 22, 2019·Reviews in the Neurosciences·Thomas BerryAhmed A Moustafa
Sep 29, 2020·Frontiers in Neuroscience·Pieter VancampSylvie Remaud
Dec 29, 2020·Frontiers in Endocrinology·Ting-Ting LinYan-Ting Wu
Jun 20, 2021·Metabolic Brain Disease·Paulina Belén Sepulveda FigueroaAndréa da Silva Torrão
Aug 24, 2021·Journal of Alzheimer's Disease : JAD·Feifei GeJingping Shi

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