Low serum creatinine is a type 2 diabetes risk factor in men and women: The Yuport Health Checkup Center cohort study

Diabetes & Metabolism
Saori KashimaKimihiko Akimoto

Abstract

Type 2 diabetes (T2D) is a risk factor for muscle loss and subsequent frailty. The reverse association, however, may also happen. This study examined whether serum creatinine level, an indicator of muscle mass, predicted diabetes development. In addition, a role for body mass index (BMI) as an effect modifier of creatinine levels was evaluated. This cohort study included 9667 subjects without diabetes or hypertension and with normal creatinine levels at baseline. Multiple-adjusted hazard ratios (HRs) for associations between baseline creatinine and diabetes development were estimated using the Cox proportional-hazards model. Stratified analyses based on BMI were also performed. During the follow-up period (mean: 5.6 years), 287 (5.5%) men and 115 (2.3%) women developed T2D. HR in men with serum creatinine≤0.7mg/dL compared with 0.9-1.2mg/dL was 1.40 (95% CI: 1.05-1.87) after adjusting for age, BMI, blood pressure and fasting plasma glucose at baseline, whereas the adjusted HR in women with creatinine≤0.5mg/dL compared with 0.7-1.1mg/dL was 1.69 (95% CI: 1.04-2.76). In a subgroup analysis stratified by BMI, interactions between BMI and baseline creatinine levels for T2D were statistically significant in women with the lowest cre...Continue Reading

Citations

Oct 30, 2018·The Cochrane Database of Systematic Reviews·Bernd RichterYemisi Takwoingi
Feb 14, 2019·Journal of Diabetes Investigation·Huanhuan HuUNKNOWN Japan Epidemiology Collaboration on Occupational Health Study Group
Nov 7, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takuro OkamuraMichiaki Fukui
Jan 19, 2020·Journal of Clinical Medicine·Yoshitaka HashimotoMichiaki Fukui
Apr 26, 2020·Endocrinología, Diabetes Y Nutrición·Carlos A Amado Diago, José A Amado Señaris
Apr 16, 2021·PeerJ·José Miguel Rodríguez-LópezIgnacio Fernández-Fígares
May 21, 2021·Experimental Gerontology·Ana Paula PillattRodolfo Herberto Schneider
Aug 27, 2021·Metabolites·Jeffrey PattersonHaiwei Gu

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