Abstract
Type 2 diabetes (T2D) is a risk factor for muscle loss and subsequent frailty. The reverse association, however, may also happen. This study examined whether serum creatinine level, an indicator of muscle mass, predicted diabetes development. In addition, a role for body mass index (BMI) as an effect modifier of creatinine levels was evaluated. This cohort study included 9667 subjects without diabetes or hypertension and with normal creatinine levels at baseline. Multiple-adjusted hazard ratios (HRs) for associations between baseline creatinine and diabetes development were estimated using the Cox proportional-hazards model. Stratified analyses based on BMI were also performed. During the follow-up period (mean: 5.6 years), 287 (5.5%) men and 115 (2.3%) women developed T2D. HR in men with serum creatinine≤0.7mg/dL compared with 0.9-1.2mg/dL was 1.40 (95% CI: 1.05-1.87) after adjusting for age, BMI, blood pressure and fasting plasma glucose at baseline, whereas the adjusted HR in women with creatinine≤0.5mg/dL compared with 0.7-1.1mg/dL was 1.69 (95% CI: 1.04-2.76). In a subgroup analysis stratified by BMI, interactions between BMI and baseline creatinine levels for T2D were statistically significant in women with the lowest cre...Continue Reading
Citations
Oct 30, 2018·The Cochrane Database of Systematic Reviews·Bernd RichterYemisi Takwoingi
Feb 14, 2019·Journal of Diabetes Investigation·Huanhuan HuUNKNOWN Japan Epidemiology Collaboration on Occupational Health Study Group
Oct 15, 2019·Human Mutation·Elizabeth A HayAlasdair MacKenzie
Nov 7, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takuro OkamuraMichiaki Fukui
Jan 19, 2020·Journal of Clinical Medicine·Yoshitaka HashimotoMichiaki Fukui
Mar 19, 2020·Journal of Diabetes·Pei QinFulan Hu
Feb 28, 2018·The Veterinary Record·Mamoru TakeuchiHiroyasu Iso
Jul 4, 2020·Environment International·Victor MondalKhaled Hossain
Feb 7, 2021·Metabolites·Jialing HuangRui Wang-Sattler
Feb 21, 2021·Biochemical Genetics·Priyanka RainaAjs Bhanwer
Apr 26, 2020·Endocrinología, Diabetes Y Nutrición·Carlos A Amado Diago, José A Amado Señaris
Apr 16, 2021·PeerJ·José Miguel Rodríguez-LópezIgnacio Fernández-Fígares
May 21, 2021·Experimental Gerontology·Ana Paula PillattRodolfo Herberto Schneider
Jul 28, 2021·Scientific Reports·Saori KashimaMasatoshi Matsumoto
Aug 27, 2021·Metabolites·Jeffrey PattersonHaiwei Gu