Low serum DHEA-S is associated with impaired lung function in women

EClinicalMedicine
Giancarlo PesceBénédicte Leynaert

Abstract

Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999-2002 and in 2010-2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999-2002 with incidence of restrictive pattern and airflow limitation in 2010-2013 were also assessed. Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women...Continue Reading

References

Jan 1, 1996·The Journal of Allergy and Clinical Immunology·R E WeinsteinD R Pieper
Nov 27, 2002·The European Respiratory Journal·UNKNOWN European Community Respiratory Health Survey II Steering Committee
Dec 6, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Nicolas Rohleder, Clemens Kirschbaum
Jan 3, 2009·The Korean Journal of Internal Medicine·Inseon S ChoiYoung Ho Won
Jan 12, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Jon HazeldineJanet M Lord
Aug 25, 2010·American Journal of Respiratory and Critical Care Medicine·Ferenc MacsaliCecilie Svanes
Dec 21, 2011·The European Respiratory Journal·Philip H QuanjerUNKNOWN Global Lungs Initiative
Jan 14, 2012·Endocrine Reviews·Elizabeth A TownsendY S Prakash
Jul 10, 2012·Biochimica Et Biophysica Acta·Cynthia J Koziol-WhiteReynold A Panettieri
May 25, 2013·Stroke; a Journal of Cerebral Circulation·Monik C JiménezKathryn M Rexrode
Apr 8, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Claes OhlssonAsa Tivesten
May 2, 2014·The Journal of Endocrinology·Luis M MontañoMercedes Perusquía
Aug 10, 2015·European Journal of Pediatrics·Ozlem CavkaytarBulent E Sekerel
Dec 3, 2016·American Journal of Respiratory and Critical Care Medicine·Kai TriebnerFrancisco Gómez Real
Feb 6, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Fernand LabrieGeorges Pelletier
Mar 31, 2017·The European Respiratory Journal·Stacey N ReinkeCraig E Wheelock
Dec 10, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Seline ZurfluhPhilipp Schuetz
Apr 11, 2018·BMC Pulmonary Medicine·Mark D DeBoerW Gerald Teague
Aug 24, 2019·The European Respiratory Journal·Diana A van der PlaatUNKNOWN ALEC project

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.