PMID: 9419771Jul 1, 1994Paper

Low serum estradiol and high serum progesterone concentrations characterize hypertensive pregnancies at high altitude

Journal of the Society for Gynecologic Investigation
S ZamudioL G Moore

Abstract

Intrauterine growth retardation and preeclampsia are more common at high than at low altitude. Because altered hormonal profiles have been linked with these disorders, we asked whether placental steroid hormone concentrations were altered during pregnancy at high altitude. We measured progesterone, unconjugated estradiol, and estriol (by radioimmunoassay) at weeks 20, 30, and 36 of pregnancy in 18 women at low altitude (1600 m) and 40 women at high altitude (3100 m). Women at 3100 m compared with 1600 m had lower serum estradiol concentrations at week 36 of pregnancy, and lower estriol and higher progesterone concentrations throughout pregnancy. As a result, the progesterone/estradiol ratio was greater in the high- versus the low-altitude women. Estradiol fell between weeks 30 and 36 in women who developed transient hypertension or preeclampsia. The fall in estradiol was accompanied by a marked increase in progesterone concentrations among the preeclamptic women. At 3100 m, estradiol correlated negatively (r = -0.37, P < .05) and progesterone positively (r = 0.46, P < .05) with mean arterial pressure at week 36 of pregnancy. We speculate that reduced placental oxygen pressure (PO2) at high altitude may decrease placental aromat...Continue Reading

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Citations

Apr 13, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M M WeigelL Mosquera
Mar 27, 2001·Pediatric Research·D A GiussaniD J Barker
Jul 12, 2003·High Altitude Medicine & Biology·Stacy Zamudio
Apr 2, 2014·The Journal of Clinical Endocrinology and Metabolism·Shelton M CharlesLorna G Moore
Jan 9, 1999·American Journal of Physical Anthropology·L G MooreS Zamudio
Jul 10, 2001·High Altitude Medicine & Biology·L G Moore
Jan 20, 2006·Cancer·Sadhna ShankarXiao-Ou Shu
Apr 11, 2007·Current Opinion in Nephrology and Hypertension·Dinesh M Shah
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Jan 1, 1995·American Journal of Human Biology : the Official Journal of the Human Biology Council·Stacy ZamudioLorna Grindlay Moore
Mar 23, 2017·Endocrine Reviews·Nadia BerkaneNathalie Chabbert-Buffet
May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
Mar 9, 2005·American Journal of Physiology. Renal Physiology·Dinesh M Shah
Sep 9, 2016·Physiological Reviews·Graham J BurtonKent L Thornburg
Aug 10, 2010·American Journal of Obstetrics and Gynecology·Alexandre HertigMarie-Edith Rafestin-Oblin
Apr 4, 2021·Antioxidants·Xiang-Qun Hu, Lubo Zhang
Jul 21, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Philippe MervielSerge Uzan
Jul 15, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathryn Wilsterman, Zachary A Cheviron
Aug 28, 2021·International Journal of Molecular Sciences·Xiangqun Hu, Lubo Zhang

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