Low Serum Hepatitis B Surface Antigen Level Predicts Compensated Cirrhosis Caused by Chronic Hepatitis B in HBeAg Positive Patients in East China

Hepatitis Monthly
Wen JiaJi-Ming Zhang

Abstract

Serum hepatitis B surface antigen (HBsAg) levels are associated with fibrosis in patients with chronic hepatitis B (CHB) infection. The aim of our study was to evaluate serum HBsAg level as a biomarker for compensated cirrhosis in hepatitis B e antigen (HBeAg) positive CHB patients. Two-hundred and one HBeAg-positive Chinese CHB patients with or without cirrhosis were enrolled in this retrospective study. Cirrhosis was diagnosed based on liver biopsy. Furthermore, patients with decompensated cirrhosis were excluded. A statistical analysis was performed regarding the association between serum HBsAg level and compensated cirrhosis. Patients with compensated cirrhosis had a significantly lower mean serum HBsAg level compared to those without cirrhosis (3.27 Log10 IU/mL VS 4.17 Log10 IU/mL, P < 0.001). Furthermore, examining the correlation with compensated cirrhosis revealed that lower level of serum HBsAg was a significant factor in multivariate analysis. The area under the receiver operating characteristics curve of serum HBsAg was 0.856 for compensated cirrhosis. A positive predictive value of 66.2% and negative predictive value of 90.7% were obtained with a cut-off value of < 3.60 Log10 IU/mL (4000 IU/mL) of serum HBsAg. Moreo...Continue Reading

References

Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
Mar 23, 2000·Journal of Hepatology·R F Butterworth
Feb 28, 2002·Seminars in Ultrasound, CT, and MR·Antonio Martínez-NogueraJordi Villalba
Mar 5, 2003·Seminars in Liver Disease·Giovanna Fattovich
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Min-De ZengXia-Qiu Zhou
May 5, 2006·Seminars in Liver Disease·Chia-Ming Chu, Yun-Fan Liaw
Dec 7, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·W G ShinC K Park
Dec 5, 2008·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Aug 12, 2009·Hepatology International·Yun-Fan LiawUNKNOWN Chronic Hepatitis B Guideline Working Party of the Asian-Pacific Association for the Study of the Liver
Jan 16, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Beom Kyung KimKwang Hyub Han
Apr 21, 2010·Pathology International·Yu-Guo ZhangXiao-Juan Ou
Jun 8, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Yu J KimSeung W Paik
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Teresa PollicinoGiovanni Raimondo
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Jun 22, 2012·World Journal of Gastroenterology : WJG·Xu-Dong LiuQing-Shou Sheng
Jun 5, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Pin-Nan ChengTing-Tsung Chang
Apr 3, 2014·Hepatitis Monthly·Simin Dokht ShoaeiEsmail Riahi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

Stata
FibroScan
APRI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.