Low serum indium levels induce expression disorders of some inflammatory factors.

International Archives of Occupational and Environmental Health
Jianping YangJing Feng

Abstract

It has been reported that occupational exposure to indium compounds, including indium-tin oxide, can induce pulmonary inflammation resulting in serious indium lung disease. However, whether there is an early effect of indium exposure on inflammatory factor expression remains unclear. Twenty indium-tin oxide processing workers and 15 healthy volunteers were recruited to measure serum indium levels, respiratory symptoms, pulmonary function, and serum inflammatory factor levels. Although low serum indium was detected in workers, lung abnormalities were not increased, compared with healthy population. However, serum G-CSF, IL-4, IL-5, TNF-alpha, and TNF-beta levels were significantly increased, while IL-16 and TIMP-1 were obviously down-regulated in indium-tin oxide processing workers. These inflammatory factor levels showed a significant correlation with serum indium levels. Basing on our findings, we speculate that low serum indium levels may induce inflammatory responses, which may be an adaptive response or may cause lung diseases. Therefore, further experiments or follow-up is needed. However, better safeguard procedures and indium exposure reduction should be considered in ITO industry.

References

Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·G A FinlayC M O'Connor
May 16, 2000·The Journal of Allergy and Clinical Immunology·H TanakaS Abe
Jun 4, 2004·Expert Opinion on Biological Therapy·Frédéric F Little, William W Cruikshank
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie Zhang-HooverJoan Stein-Streilein
Feb 21, 2006·Environmental Research·Arun B JosyulaJefferey L Burgess
Aug 12, 2006·Journal of Occupational and Environmental Medicine·Yen-Hsiung LiaoTar-Ching Aw
Oct 20, 2006·The European Respiratory Journal·T ChonanK Omae
Jan 30, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dominique LisonBice Fubini
Oct 17, 2009·Journal of Occupational Health·Makiko NakanoTatsuya Chonan
Sep 3, 2010·Recent Patents on Inflammation & Allergy Drug Discovery·Dhananjay Desai, Christopher Brightling
Oct 5, 2010·International Archives of Occupational and Environmental Health·Kazuyuki OmaeTatsuya Chonan
Jan 15, 2011·Journal of Occupational Health·Kasuke NaganoShoji Fukushima
Mar 23, 2011·Journal of Occupational Health·Kasuke NaganoShoji Fukushima
Apr 8, 2011·Journal of Occupational Health·Kasuke NaganoShoji Fukushima
Dec 31, 2011·Chest·Kristin J CummingsKathleen Kreiss
Sep 17, 2013·Trends in Immunology·Julie DeckersHamida Hammad
Jun 7, 2015·Toxicology and Applied Pharmacology·Edgar Olivas-CalderónJorge A Espinosa-Fematt
May 25, 2016·American Journal of Industrial Medicine·Kristin J CummingsKathleen Kreiss
Jun 28, 2016·Environmental Toxicology and Pharmacology·Ernst M Bomhard

❮ Previous
Next ❯

Citations

Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka MaruszewskaIzabela Gutowska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Z MinD Y Sun
Journal of Hazardous Materials
Hsin-Fang ChangKuo-Chen Yeh
The Tohoku Journal of Experimental Medicine
Tatsuya ChonanKazuyuki Omae
© 2022 Meta ULC. All rights reserved